7-Bromoquinolin-8-ol

General procedure: To synthesize brominated 8-substituted quinolines (5-10) experimental procedures were repeated in literature [19]. In brief, to a solution of 8-substituted quinoline 2-4 (2 mmol, 1 eq) in distilled CHCl3 (15 mL) was added a solution of molecular bromine (different eqivalents) in CHCl3 over 10 min in the dark at ambient temperature and stirred for 2 days. The reaction was monitored by TLC; after completion of the reaction, the organic layer was washed with 5percent NaHCO3 (3 × 20 mL), dried over Na2SO4, and concentrated under reduced pressure. The products was isolated by alumina column, eluting with AcOEt/hexane (1:5, 150 mL).General procedure: Complexes 1-4 were prepared at room temperature. The appropriateamount of ligand XQ (78 mg (0.36 mmol) of dClQ (1); 39 mgof dClQ (2), 56 mg of dBrQ (3) and 41 mg of BrQ (4) what represents0.18 mmol) was dissolved in 5 mL of DMF. While continuouslystirring, KOH (60 mg), which had been previously dissolvedin a small amount of water was added dropwise. Subsequently, an ethanolic solution of zinc chloride (ZnCl2 in 5 mL of ethanol)was added (25 mg (0.18 mmol) for 1, 2; 50 mg (0.36 mmol) for 3, 4), thus the resulting ratio XQ:ZnCl2 = 2:1 (1), 1:1 (2) and 1:2 (3and 4).To

Molecular Weight:224.05
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:222.96328
Monoisotopic Mass:222.96328
Topological Polar Surface Area:33.1
Heavy Atom Count:12
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes