4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
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![4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/6f6c0cb1d10841dfa1c97e3cff08c354.png "4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde")
4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
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CAS No:
1000340-35-1
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Formula:
C8H5BrN2O
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Chemical Name:
4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
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Synonyms:
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde,4-bromo-;4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
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CAS No:
4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde Basic Attributes
225
225.04
DTXSID20646883
2933990090
4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde Use and Manufacturing
Preparation of 1-methyl-4-phenyl-1H-pyrrolo[2, 3-b]pyridine-3-carbaldehyde (Formula 17); A solution of 70percent mCPBA (11.54 g, 66.87 mmole) in ethyl acetate (25 mL) was added by drops to a solution of 7-azaindole (Formula 11, 5 g, 42.3 mmole) in ethyl acetate (40 mL) at 0° C. with a good stirrer. After addition was completed, the mixture was stirred at room temperature for 1 to 2 hours until no starting material left. The mixture was cooled, filtered, and washed with ethyl acetate to give a solid. It was dissolved in 50 mL of water and treated with 30percent KA solution of 1-(4-bromo-1 H-pyrrolo[2, 3-b]pyridin-3-yl)-N, N-dimethylmethanamine (341 mg, 1.34 mmol) and hexamethylenetetramine (190 mg, 1.34 mmol) in 66percent propionic acid was added by drops to a refluxing solution of hexamethylenetetramine (190 mg, 1.34 mmol) in 66percent propionic acid (0.8 mL) at 12OTo a stirred solution of 4-bromo-1H-pyrrolo[2, 3-b]pyridine (10 g, 15.02 mmol) in water (80 mL), was added hexamethylenetetramine (10.7 g, 76.53 mmol) and acetic acid (20 mL). The reaction mixture was heated at 100 C. for 16 hours. The reaction mixture was cooled to ambient temperature and poured into water. The precipitated solid was filtered, washed with water and dried in vacuum to provide A suspension of sodium hydride (2.16 g, 45.19 mmol) in N, N-dimethylformamide (80 mL) was treated with
Computed Properties
Molecular Weight:225.04
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:223.95853
Monoisotopic Mass:223.95853
Topological Polar Surface Area:45.8
Heavy Atom Count:12
Complexity:188
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
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Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 1000340-35-1Grade: Industrial GradeContent: 95%
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4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
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