1-Bromo-2-chloro-4-methoxybenzene

Light yellow liquid

General procedure: To a reaction tube charged with NBS (1.5 equiv, 0.3 mmol), catalyst (10 molpercent, 0.02 mmol) and CHPreparation of 1-bromo-2-chloro-4-methoxy benzene 356 mg (1.76 mmol) of 4-bromo-3-chlorophenol was dissolved in 20 ml of dimethylformamide, and 365 mg (2.64 mmol) of potassium carbonate and 0.13 ml (2.11 mmol) of iodomethane were added thereto, followed by stirring at room temperature. After 2 hours, the solvent was removed in vacuo, the residue was dissolved in 100 ml of ethyl acetate and washed with 50 ml of water and 50 ml of saturated aqueous NACI, then dried over anhydrous MGS04. The crude compound, obtained after removing the solvent in VACUO, was purified by column chromatography (HEXANE/ETHYL ACETATE = 9/1, v/v) to give 275 mg (1.24 mmol) of the title compound at 70.7percent yield. 1H NMR (CDCL3, PPM) ; 8 7. 89 (1H, s), 7.43 (1H, d), 7.21 (1H, d), 4.22 (3H, s) FAB MS (m/e) = 222 [M+1]

Molecular Weight:221.48
XLogP3:3.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:219.92906
Monoisotopic Mass:219.92906
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes