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Home > Encyclopedia > 4-(Bromomethyl)-2,6-dichloropyridine

4-(Bromomethyl)-2,6-dichloropyridine

4-(Bromomethyl)-2,6-dichloropyridine structure

4-(Bromomethyl)-2,6-dichloropyridine 

structure
  • CAS No:

    175204-45-2

  • Formula:

    C6H4BrCl2N

  • Chemical Name:

    4-(Bromomethyl)-2,6-dichloropyridine

  • Synonyms:

    Pyridine,4-(bromomethyl)-2,6-dichloro-;4-(Bromomethyl)-2,6-dichloropyridine;4-Bromomethyl-2,6-dichloropyridine;(2,6-Dichloropyridin-4-yl)methyl bromide

  • Categories:

    Chemical Reagents  >  Organic Reagents

4-(Bromomethyl)-2,6-dichloropyridine Basic Attributes

240.91

240.91

DTXSID90381870

29333999

Characteristics

12.9

3.3

Yellow Crystalline Powder

1.770±0.06 g/cm3(Predicted)

299.2±35.0 °C(Predicted)

134.8±25.9 °C

1.604

0.00215mmHg at 25°C

Safety Information

36/37/38

26-36/37/39

T

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501

H301+H311+H331

|Danger|H301+H311+H331 (98.73%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 158 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-(Bromomethyl)-2,6-dichloropyridine Use and Manufacturing

To a solution of (2, 6-dichloropyridin-4-yl)methanol [0794] in tetrahydrofuran was added triphenylphosphine and N-bromosuccinimide at 0° C. and the reaction mixture was stirred at same temperature. After 2 h, the reaction mixture was diluted with water and extracted with ethyl acetate (3×150 mL). The combined organic layer was washed with brine (2×100 mL), dried over anhydrous sodium sulfate, filtered and concentrated to afford a crude product which was purified by column chromatography to afford 1.1 g of 4-(bromomethyl)-2, 6-dichloropyridine [0795] as colorless liquid. MS(M+1)+=241.8.

Computed Properties

Molecular Weight:240.91
XLogP3:3.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:238.89042
Monoisotopic Mass:238.89042
Topological Polar Surface Area:12.9
Heavy Atom Count:10
Complexity:102
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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