6-Bromo-1-methylpyridin-2(1H)-one
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6-Bromo-1-methylpyridin-2(1H)-one
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CAS No:
873383-11-0
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Formula:
C6H6BrNO
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Chemical Name:
6-Bromo-1-methylpyridin-2(1H)-one
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Synonyms:
2(1H)-Pyridinone,6-bromo-1-methyl-;2(1)-Pyridone,6-bromo-1-methyl-;6-Bromo-1-methyl-2(1H)-pyridinone;6-Bromo-1-methylpyridin-2(1H)-one;6-Bromo-1-methyl-1,2-dihydropyridin-2-one;6-Bromo-N-methylpyridin-2-one;6-Bromo-1-methylpyridin-2-one
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
6-Bromo-1-methylpyridin-2(1H)-one Use and Manufacturing
General procedure: In a dry Schlenk tube 6-methyl-2(1H)-pyridone (1) (3.43 g, 31.44 mmol) was dissolved in 50 mLof 1, 4-dioxane and KOt-Bu (8.69 g, 62.88 mmol) was added. The mixture was stirred at 100 °C for 2 h, then cooled down to rt, MeI (19.6 mL, 314.41 mmol) was added dropwise and the mixture was stirred at 80 °C for 16 h. The solvent was removed under reduced pressure and the residue was separated between DCM and water. The extraction was performed using DCM (3×) and the combined organic phases were dried over MgSOTo a solution of compound 12-1 (1 g, 5.78 mmol) in DME (20 ml) was added K6-Bromo-1 -methylpyridin-2(1 H)-one
Computed Properties
Molecular Weight:188.02
XLogP3:1.3
Hydrogen Bond Acceptor Count:1
Exact Mass:186.96328
Monoisotopic Mass:186.96328
Topological Polar Surface Area:20.3
Heavy Atom Count:9
Complexity:195
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
6-Bromo-1-methylpyridin-2(1H)-one
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