6-bromopyrido[2,3-d]pyrimidin-2-amine

Synthesis of 6-bromopyrido [2, 3-d]pyrimidin-2-amine. 5-bromo-2-fluoronicotinaldehyde (3.0 g, 14.78 mmol), guanidine hydrochloride (1.69 g, 17.74 mmol) and triethylamine (4.48 g, 44.35 mmol) were dissolved in 1-methyl-2-pyffolidinone(15 mL), and the reaction mixture was stirred at 180 °C for 15 mm under microwave. Themixture was cooled to RT, quenched with water (200 mL) and extracted with ethyl acetate (2 x300 mL). The organic layers were combined, washed with water (3 x 50 mL) and brine (3 x 50mL), dried over sodium sulfate, filtered, and concentrated to afford a crude product, which was purified by silica gel column chromatography (ethyl acetate:petroleum ether = 3 : 1) to afford 6- bromopyrido[2, 3-d]pyrimidin-2-amine (2.0 g, 60 percent) as a yellow solid. MS (ES+) C7H5BrN4 requires: 224, 226, found: 225, 227 [M+H].

Molecular Weight:225.05
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:223.96976
Monoisotopic Mass:223.96976
Topological Polar Surface Area:64.7
Heavy Atom Count:12
Complexity:166
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes