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CGP 52432

CGP 52432 structure

CAS No:
139667-74-6
Formula:
C15H24Cl2NO4P
Chemical Name:
CGP 52432
Synonyms:
(3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl) phosphinic acid;CGP 52432;CGP-52432;Phosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)-;CGP52432;3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid;Tocris-1246
Categories:
Organic Chemistry > Amides

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Description

CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.

3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.

CGP 52432 Basic Attributes

Molecular Weight：

384.24

Exact Mass：

383.08200

EC Number：

-0

DSSTox ID：

DTXSID20161147

Characteristics

PSA：

67.8

XLogP3：

Appearance：

white to beige

Density：

1.258±0.06 g/cm3(Predicted)

Boiling Point：

544.4±50.0 °C(Predicted)

Flash Point：

283.1ºC

Refractive Index：

1.524

Water Solubility：

H2O: soluble1mg/mL, clear (warmed)

Storage Conditions：

Desiccate at +4°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

(3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl) phosphinic acid

CGP 52432 Use and Manufacturing

Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).

Computed Properties

Molecular Weight:384.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:383.0820006
Monoisotopic Mass:383.0820006
Topological Polar Surface Area:67.8
Heavy Atom Count:23
Complexity:369
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes