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CGP 57380

CGP 57380 structure

CAS No:
522629-08-9
Formula:
C11H9FN6
Chemical Name:
CGP 57380
Synonyms:
CGP 57380;CGP57380,N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine;MNK1 Inhibitor;N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Categories:
Organic Chemistry > Amides

Description

CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

N3-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine is a pyrazolopyrimidine.

CGP 57380 Basic Attributes

Molecular Weight：

244.232

Exact Mass：

244.087280

NSC Number：

741567

DSSTox ID：

DTXSID50469941

Characteristics

PSA：

92.5

XLogP3：

2.3

Appearance：

white to beige

Density：

1.6±0.1 g/cm3

Boiling Point：

541.635°C at 760 mmHg

Flash Point：

281.4±30.1 °C

Refractive Index：

1.809

Water Solubility：

DMSO: soluble 10mg/mL, clear

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H319

GHS Classification：

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

CGP 57380

Computed Properties

Molecular Weight:244.23
XLogP3:2.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:244.08727247
Monoisotopic Mass:244.08727247
Topological Polar Surface Area:92.5
Heavy Atom Count:18
Complexity:283
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of CGP 57380

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

MNK1 Inhibitor

CAS No.: 522629-08-9

Content: 99.00%

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Compound Net Biotechnology Inc. Contact Supplier

CN
2 YRS

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Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

522629-08-9 3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

CAS No.: 522629-08-9

Grade: Industrial Grade

Content: 95%

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