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6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide structure

CAS No:
181632-25-7
Formula:
C21H19ClN4O2
Chemical Name:
6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide
Synonyms:
1H-Indole-1-carboxamide,6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-;6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide;SB 242084
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Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

SB 242084 is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.3, whi

6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator.

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide Basic Attributes

Molecular Weight：

467.775

Exact Mass：

394.85

DSSTox ID：

DTXSID70394600

Characteristics

PSA：

67.35000

XLogP3：

3.76

Appearance：

white to beige

Density：

1.4±0.1 g/cm3

Melting Point：

181-183 °C

Boiling Point：

620.1±55.0 °C at 760 mmHg

Flash Point：

328.8±31.5 °C

Refractive Index：

1.671

Water Solubility：

DMSO: soluble 15mg/mL, clear

Storage Conditions：

2-8°C

Safety Information

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide Use and Manufacturing

SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.

Computed Properties

Molecular Weight:467.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:466.073009
Monoisotopic Mass:466.073009
Topological Polar Surface Area:67.4
Heavy Atom Count:30
Complexity:551
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Recommended Suppliers of 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide

Xi'an Horlden Bio-Tech Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Chemical,Intermediate,5-amino-1mq,SLU-PP332,Tirzepatide,Peptide,KY19382,5-deazaflavin,Dihexa,Urolithin A

High Quality Pure 98% HPLC SB 242084 Hydrate Dihydrochloride CAS 181632-25-7

Unit Price: $1000-1250 /G FOB

CAS No.: 181632-25-7

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

SB 252084-181632-25-7-high purity 99%-high purity 99%-high purity 99%high purity 99%high purity 99%high purity 99%

CAS No.: 181632-25-7

Grade: Pharmaceutical Grade

Content: 99%

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Latest News on 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide

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Guide of 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide

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