1-Chloro-3-iodo-5-nitrobenzene

In a Schlenk reaction tube equipped with a magnetic stirrer, 6.7 mg of palladium trifluoroacetate was added.Cuprous oxide 28.6 mg, phosphorusPotassium 6.4mg, 4-chloro-2-nitrobenzoic acid 40.3 mg, Sodium iodide 36mg, bismuth nitrate pentahydrate 194mg and 2mL of dimethyl Sulfoxide.The reaction was heated at 170°C for 20 hours in the presence of oxygen. After the reaction is completed, distilled water is added to quench the reaction.useEthyl acetate was extracted 3 times.10 mL each, the combined organic phases are concentrated to give 1-chloro-3-iodo-5-nitrobenzene41.4 mg, yield 73percent.

Molecular Weight:283.45
XLogP3:3
Hydrogen Bond Acceptor Count:2
Exact Mass:282.88970
Monoisotopic Mass:282.88970
Topological Polar Surface Area:45.8
Heavy Atom Count:11
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes