2-Chloro-4,4′-bipyridine

Procedure for Preparation of 2-amino-[4, 4']-bipyridine The title compound was prepared by heating 2-chloro-[4, 4']bipyridinyl and NH4OH (30% in H2O) in a bomb at 210 C. for 48 hours: MS (m/z): Calcd. C10H9N3 (M+): 171, found (M+H)+: 172.1To a mixture of (S)-tert-butyl 2-amino-4-(((S)-2-fluoro-3-methoxypropyl) (4-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) butyl)amino) butanoate (150 mg, 331 mumol) and 2-chloro-6-phenylpyrazine (53 mg, 276 mumol) in t-AmOH (3 mL) was added 2.0M t-BuONa in THF (276 muL, 552 mumol) then t-BuXPhos Pd G3 (22 mg, 28 mumol) and the resulting mixture was heated to 100 C. for 5 h, cooled to rt, and then concentrated in vacuo to give the title compound that was used without further purification. LCMS (ESI+): m/z=607.2 (M+H)+.

Molecular Weight:190.63
XLogP3:2.4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:190.0297759
Monoisotopic Mass:190.0297759
Topological Polar Surface Area:25.8
Heavy Atom Count:13
Complexity:157
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes