 Home > Encyclopedia > Chaetoglobosin A

Chaetoglobosin A

Chaetoglobosin A structure

CAS No:
50335-03-0
Formula:
C32H36N2O5
Chemical Name:
Chaetoglobosin A
Synonyms:
3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione,4,7,14,14a,15,15a,16a,16b-octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-,(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-;[13]Cytochalasa-13,17,21-triene-1,20,23-trione,6,7-epoxy-19-hydroxy-10-(1H-indol-3-yl)-16,18-dimethyl-,(7S,13E,16S,17E,19R,21E)-;(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione;Chaetoglobosin A;3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione,4,7,14,14a,15,15a,16a,16b-octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-,[4S-(1E,4R*,5E,7S*,9E,11aS*,14R*,14aS*,15R*,15aS*,16aR*,16bS*)]-

Description

Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration[1].

Chaetoglobosin A Basic Attributes

Molecular Weight：

528.64

Exact Mass：

528.64

Characteristics

PSA：

111.79000

XLogP3：

4.16120

Density：

1.3 g/cm3

Melting Point：

188°C

Boiling Point：

789.7ºC at 760 mmHg

Flash Point：

431.4ºC

Refractive Index：

1.651

Water Solubility：

DMSO: soluble 10mg/mL

Storage Conditions：

-20°C

Toxicity：

Oral-rat LD50: > 400 mg/kg; Oral-Mouse LD50: > 400 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

GHS Classification：

|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Computed Properties

Molecular Weight:528.6
XLogP3:3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:528.26242225
Monoisotopic Mass:528.26242225
Topological Polar Surface Area:112
Heavy Atom Count:39
Complexity:1140
Defined Atom Stereocenter Count:9
Undefined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

dehydrotanshinone II A

119963-50-7
Megalomicin A bis(potassium dihydrogen phosphate)

23319-48-4
methylenecyclopropyl acetyl-coenzyme A

56898-43-2
2-Propenenitrile, polymer with 1,3-butadiene, carboxy-terminated, polymer with bisphenol A diglycidyl ether Formula

68648-83-9
A 802715 Formula

107767-58-8
9a-aza-9a-homo Erythromycin A Formula

76820-32-1
gymnochrome A Structure

137363-67-8
Purpurea glycoside A Structure

19855-40-4
What is Petuniasterone A

114175-99-4
What is A 71623

130408-77-4

Hot Searches: cellulose sodium eye drops; pseudomembranous colitis; flunarizine; ca hypochlorite; bioglutide; oxycycline

Guide of Chaetoglobosin A

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Computed Properties
Learn More Other Chemicals

Chaetoglobosin A

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.