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CETUXIMAB

CETUXIMAB structure

CAS No:
205923-56-4
Formula:
C6484H10042N1732O2023S36
Chemical Name:
CETUXIMAB
Synonyms:
CETUXIMAB;Erbitux;Hsdb 7454;Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 gamma1-chain), disulfide with human-mouse monoclonal C225 kappa-chain, dimer;Unii-pqx0D8J21j;EGFR antibody;IMC 225;CetuxiMab(C225)
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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CETUXIMAB Basic Attributes

Molecular Weight：

2756.23406

Exact Mass：

226.110611

Characteristics

XLogP3：

3.51

Density：

1.0±0.1 g/cm3

Boiling Point：

371.9±44.0 °C at 760 mmHg

Flash Point：

178.7±28.4 °C

Refractive Index：

1.554

CETUXIMAB Use and Manufacturing

Treatment of EGF receptor-expressing cancers (monoclonal antibod.

Drug Function and Efficacy

This product can specifically bind to the EGF receptor expressed on the surface of normal cells and various cancer cells, and competitively block the binding of EGF and other ligands, such as transforming growth factor-α (TGF-α). By inhibiting the tyrosine kinase (TK) that binds to the EGF receptor, it blocks the intracellular signal transduction pathway, thereby inhibiting the proliferation of cancer cells, inducing apoptosis of cancer cells, and reducing the production of matrix metalloproteinases and vascular endothelial growth factor.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cetuximab Injection
Ingredients	Each 50 ml solution of this product contains: Active ingredient: Cetuximab 100 mg Other ingredients: Sodium dihydrogen phosphate 20 mg; Sodium hydrogen phosphate 66 mg; Sodium chloride 424 mg; Add water for injection to 50 ml.
Specifications	100mg/20ml/bottle

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