 Home > Encyclopedia > Cetrorelix acetate

Cetrorelix acetate

Cetrorelix acetate structure

CAS No:
130143-01-0
Formula:
C70H92N17O14
Chemical Name:
Cetrorelix acetate
Synonyms:
N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide diacetate;Cetrorelix acetate;Cetrorenlin Acetate;Cetrelix Acetate
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Cetrorelix acetate is the acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent. It is an oligopeptide and an acetate salt. It contains a cetrorelix.

Cetrorelix acetate Basic Attributes

Molecular Weight：

1551.16

Exact Mass：

1429.669800

UNII：

XPQ226310Q

ATC Code：

H01CC02

Characteristics

PSA：

498

Appearance：

Solid

Density：

1.4±0.1 g/cm3

Boiling Point：

1768.4°C at 760 mmHg

Flash Point：

1023.3ºC

Refractive Index：

1.668

Water Solubility：

6.94e-03 g/L

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

hazard class code：

6.1

GHS Classification：

|Danger|H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Prevention of premature ovulation in patients undergoing a controlled ovarian stimulation, followed by oocyte-pick-up and assisted-reproductive techniques.In clinical trials, Cetrotide was used with human menopausal gonadotropin (HMG), however, limited experience with recombinant follicule-stimulating hormone (FSH) suggested similar efficacy.

MeSH：

Compounds which increase the capacity to conceive in females. (See all compounds classified as Fertility Agents, Female.)|Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. (See all compounds classified as Hormone Antagonists.)

MeSH Entry Terms：

cetrorelix

Cetrorelix acetate Use and Manufacturing

Use Classification：

Human drugs -> Cetrotide -> EMA Drug Category|Pituitary and hypothalamic hormones and analogues -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:1491.1
Hydrogen Bond Donor Count:17
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:38
Exact Mass:1489.6909477
Monoisotopic Mass:1489.6909477
Topological Polar Surface Area:536
Heavy Atom Count:106
Complexity:2870
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Cetrorelix acetate

Dingwang Technology (Wuhan) Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of API,nutrition supplements,plant extract,peptide,HCG

Cetrorelix Acetate / Cetrorelix Peptide Powder cas 120287-85-6 for Anti Cancer with Best Price

CAS No.: 130143-01-0

Grade: Top Product

Content: 98%

Inquiry
Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

Cetrorelix acetate

CAS No.: 130143-01-0

Grade: chemical grade

Content: 99%

Inquiry
Changzhou Xuanming Pharmaceutical Techno Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Peptides,Chemicals,API,Additives

High Purity Cetrorelix acetate 130143-01-0

CAS No.: 130143-01-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry