2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
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![2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/8e93af8b81cb47149284c9e3820a8d02.png "2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine")
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
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CAS No:
1060816-67-2
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Formula:
C7H6ClN3
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Chemical Name:
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
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Synonyms:
2-CHLORO-7-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE;2-chloro-7-methylpyrrolo[2,3-d]pyrimidine;SCHEMBL844838;DTXSID10725575;CS-D1752;KS-000003JC;ZINC84236052;AKOS016000336;DS-0960;PB13581
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CAS No:
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine Basic Attributes
167.59564
167.025024
DTXSID10725575
2933990090
2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine Use and Manufacturing
Step-1: 2-Chloro-7-methyl-7H-pyrrolo[2, 3-d]pyrimidine [0182] To a stirred solution of 2-chloro-7H-pyrrolo[2, 3-d]pyrimidine (1 g, 6.5 mmol) in MeCN (25 mL) at 5 Step 1. 2-chloro-7-methyl-7H-pyrrolo[2, 3-d]pyrimidineTo a solution of 2-chloro-7H-pyrrolo[2, 3-d]pyrimidine (27 mg, 0.16 mmol, prepared as reported in Bioorganic and Medicinal Chemistry Letters, 16(22), 5778-5783 (2006)) in DMF (0.15 mL) was added potassium carbonate (67 mg, 0.48 mmol), followed by methyl iodide (10 microL, 0.16 mmol). The mixture was stirred in a sealed vial at RT for 3 h. The reaction was diluted with DCM and acetonitrile, filtered and concentrated. The product was purified by flash column chromatography on silica gel, eluting with 0-50percent ethyl acetate in hexanes to afford product as a white solid (13 mg, 47percent). LCMS (M+H)To a solution of NaH (106.6 mg, 2.67 mmol) in THF (5 mL) was added 2-chloro- 7H-pyrrolo[2, 3-d]pyrimidine (500 mg, 2.54 mmol) at 0°C and stirred for 30 minutes at the same temperature. CH
Computed Properties
Molecular Weight:167.59
XLogP3:1.6
Hydrogen Bond Acceptor Count:2
Exact Mass:167.0250249
Monoisotopic Mass:167.0250249
Topological Polar Surface Area:30.7
Heavy Atom Count:11
Complexity:153
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
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