4-chloro-6,7-dimethoxy-2-methylquinazoline

2.50 g (1 1.4 mmol) of 6, 7-dimethoxy-2-methylquinazolin-4-ol were suspended in 1 1.00 mL of thionyl chloride, admixed with 10 drops of N, N-dimethylformamide and stirred for 1 h at 80°C. The thionyl chloride was removed in vacuo. The residue was admixed twice with in each case 20 mL of toluene and evaporated to dryness in vacuo. With ice bath cooling, 20 mL of a 5N sodium hydroxide solution were added dropwise to the residue. The suspension was admixed with 20 mL of dichloromethane and vigorously stirred for 10 min. The phases were separated and the aqueous phase was extracted by shaking five times with in each case 20 mL of dichloromethane. The combined organic phases were dried over sodium sulphate, filtered and evaporated to dryness in vacuo. 2.71 g (100percent of theory) of the title compound were isolated as a beige solid. 1H-NMR (400 MHz, CDCIStep b

Molecular Weight:238.67
XLogP3:2.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:238.0509053
Monoisotopic Mass:238.0509053
Topological Polar Surface Area:44.2
Heavy Atom Count:16
Complexity:242
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes