2-CHLOROQUINOLINE-6-CARBALDEHYDE

The 1 :8 mixture of brominated quino lines 7.5 (3 g, 9.24 mmol, 1 equiv) and hexamethylenetetramine (3.89 g, 28 mmol, 3 equiv) were heated to reflux in 50percent aqueous ethanol (16 mL) for 1 h. After cooling to RT, water (10 mL) was added followed by the slow addition of 12N HCl (1.50 mL) over 5 min. The reaction mixture was heated to reflux for 0.5 h then cooled to RT. The reaction mixture was added to brine and extracted with DCM 4X. The collected organics were washed with brine 2X, dried (Na

Molecular Weight:191.61
XLogP3:2.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:191.0137915
Monoisotopic Mass:191.0137915
Topological Polar Surface Area:30
Heavy Atom Count:13
Complexity:197
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes