CONGLOBATIN
-
CONGLOBATIN
structure -
-
CAS No:
72263-05-9
-
Formula:
C28H38N2O6
-
Chemical Name:
CONGLOBATIN
-
Synonyms:
CONGLOBATIN;(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;FW-04-806;Conglobatin, >=99%
-
CAS No:
CONGLOBATIN Use and Manufacturing
Isolated from Streptomyces conglobatus, conglobatin has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.
Computed Properties
Molecular Weight:498.6
XLogP3:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:498.27298694
Monoisotopic Mass:498.27298694
Topological Polar Surface Area:105
Heavy Atom Count:36
Complexity:746
Defined Atom Stereocenter Count:6
Defined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes