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8-Chloro-cAMP

8-Chloro-cAMP structure

CAS No:
41941-56-4
Formula:
C10H11ClN5O6P
Chemical Name:
8-Chloro-cAMP
Synonyms:
Adenosine,8-chloro-,cyclic 3′,5′-(hydrogen phosphate);4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,adenosine deriv.;8-Chloroadenosine 3′,5′-cyclic phosphate;8-Chloro-cyclic AMP;8-Chloro-cAMP;NSC 614491;Tocladesine;8-Chloroadenosine 3′,5′-cyclic monophosphate;NSC 284751;Adenazole;133561-53-2;55601-41-7
Categories:
Biochemical Engineering > Saccharides

Description

Tocladesine has been used in trials studying the treatment of Colorectal Cancer and Multiple Myeloma and Plasma Cell Neoplasm.|Tocladesine is an antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis.

8-Chloro-cAMP Basic Attributes

Molecular Weight：

363.65

Exact Mass：

363.65

UNII：

BQ94Z7E5OR

NCI Thesaurus Code：

C2571

Characteristics

PSA：

164.65000

XLogP3：

0.41720

Density：

2.55 g/cm3

Boiling Point：

731.7ºC

Flash Point：

396.3ºC

Refractive Index：

2.009

Water Solubility：

aqueous base: soluble

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

AU7357552

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Biologically active substances whose activities affect or play a role in the functioning of the immune system. (See all compounds classified as Immunologic Factors.)

MeSH Entry Terms：

8-chloro-cAMP

Computed Properties

Molecular Weight:363.65
XLogP3:-1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:1
Exact Mass:363.0135478
Monoisotopic Mass:363.0135478
Topological Polar Surface Area:155
Heavy Atom Count:23
Complexity:532
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 8-Chloro-cAMP

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Learn More Other Chemicals

8-Chloro-cAMP

SDS

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