2-Chloro-4-hydroxybenzaldehyde

Diisobutylaluminium hydride (1M in hexane, 240 mL, 240 mmol) was added to a solution of 2-chloro-4-hydroxybenzonitrile (15 g, 97.7 mmol) in tetrahydrofuran (200 mL), cooled to -78° C., and the mixture was stirred at this temperature for 1 hour then at room temperature for 18 hours. lntermediate 14; 2-Chloro-4-hydroxybenzaldehyde. 3-Ghlorophenol (CAS 108-43-0)(49.2 g, 0.380 mol), calcium hydroxide (122.0 g), and sodium carbonate (139.4 g) were suspended in water (872 mL). Chloroform (90.6 g, 0.760 mol) was added for 80 min, and the mixture was refluxed under vigorous stirring for 3 h. The reaction mixture was cooled on ice bath. Concentrated HCI (385 mL) and chloroform (300 mL) were added. The aqueous layer was discarded. The organic one was dried with anhydrous NaTo a solution of compound B7 (150 g, 1.17 mol), calcium hydroxide (375 g, 5.07 mol), and sodium carbonate (420 g, 3.96 mol) in 1.5 L of water was added chloroform (270 g, 2.29 mol) for 80 min, and the mixture was refluxed under NSynthesis of Compound B8: To a solution of compound B7 (150 g, 1.17 mol), calcium hydroxide (375 g, 5.07 mol), and sodium carbonate (420 g, 3.96 mol) in 1.5 L of water was added chloroform (270 g, 2.29 mol) for 80 min, and the mixture was refluxed under N

Molecular Weight:156.56
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:155.9978071
Monoisotopic Mass:155.9978071
Topological Polar Surface Area:37.3
Heavy Atom Count:10
Complexity:127
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes