CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
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CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
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CAS No:
66774-02-5
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Formula:
C19H15ClO
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Chemical Name:
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
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Synonyms:
(o-Chlorophenyl)diphenylmethanol;CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL;2-CHLOROPHENYL DIPHENYL METHANOL;(O-CHLOROPHENYL)DIPHENYL MENTHANOL;2-Chloro-,-diphenylbenzenemethanol;2-Chlorotrityl alcohol;2-Chloro-α,α-diphenylbenzyl alcohol;α,α-Diphenyl-2-chlorobenzenemethanol
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CAS No:
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Basic Attributes
294.7748
294.08100
77N69DJ59Q
170882
DTXSID80305489
2906299090
Characteristics
20.23000
4.62420
1.216g/cm3
91-92 °C(Solv: acetic acid (64-19-7))
447.6ºC at 760 mmHg
224.5ºC
1.627
Safety Information
P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, P501
H302
|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 91 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Use and Manufacturing
Use o-chlorobenzoic acid and ethanol to esterify with sulfuric acid or p-toluenesulfonic acid to produce ethyl o-chlorobenzoate, and then condense with phenylmagnesium bromide (Grignard reaction) to obtain (2-chlorophenyl) di Phenyl methanol magnesium salt, the latter obtained by hydrolysis of sulfuric acid.
(2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is a degradation product of the antifungal agent Clotrimazole (C587400).
Computed Properties
Molecular Weight:294.8
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:294.0811428
Monoisotopic Mass:294.0811428
Topological Polar Surface Area:20.2
Heavy Atom Count:21
Complexity:300
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
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