2-Chloro-3-fluoro-6-methylpyridine
-
2-Chloro-3-fluoro-6-methylpyridine
structure -
-
CAS No:
374633-32-6
-
Formula:
C6H5ClFN
-
Chemical Name:
2-Chloro-3-fluoro-6-methylpyridine
-
Synonyms:
Pyridine,2-chloro-3-fluoro-6-methyl-;2-Chloro-3-fluoro-6-methylpyridine
- Categories:
-
CAS No:
2-Chloro-3-fluoro-6-methylpyridine Use and Manufacturing
In a sealed tube, a mixture of Step 1SM-4 SM-5a B-1a2-Chloro-3-fluoro-6-methylpyrimidine SM-4 (1.0 g, 6.9 mmol), 1-Boc-4-(methylamino)- piperidine SM-5a (2.95 g, 13.7 mmol), Pd2(dba)3 (190 mg, 0.2 mmol), DavePhos (324 mg, 0.8 mmol) and LiHMDS (34.35 mL, 134.35 mmol) are taken-up in dry THF (20 mL) and the resulting mixture is flushed with argon and stirred for 45 min at 80 C. The reaction mixture is diluted with DCM, washed with H20 and brine. The organic layer is dried, filtered and concentrated under reduced pressure. Isolute is added, the solvent is removed in vacuo and the residue is purified via NP-MPLC. The product containing fractions of B-1a are combined and concentrated in vacuo.2-Chloro-3-fluoro-6-methylpyrimidine SM-4 (1.0 g, 6.9 mmol), 1-Boc-4-(methylamino)piperidine SM-5a (2.95 g, 13.7 mmol), Pd2(dba)3 (190 mg, 0.2 mmol), DavePhos (324 mg, 0.8 mmol) and LiHMDS (34.35 mL, 134.35 mmol) are taken-up in dry THF (20 mL) and the resulting mixture is flushed with argon and stirred for 45 min at 80 C. The reaction mixture is diluted with DCM, washed with H2O and brine. The organic layer is dried, filtered and concentrated under reduced pressure. Isolute is added, the solvent is removed in vacuo and the residue is purified via NP-MPLC. The product containing fractions of B-1a are combined and concentrated in vacuo.
Computed Properties
Molecular Weight:145.56
XLogP3:2.3
Hydrogen Bond Acceptor Count:2
Exact Mass:145.0094550
Monoisotopic Mass:145.0094550
Topological Polar Surface Area:12.9
Heavy Atom Count:9
Complexity:99.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Chloro-3-fluoro-6-methylpyridine
-
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of fine chemicals,pharmaceutical materials -
![China]()
CN
2 YRS
Business licensedTrader Supplier of Pharmaceutical intermediatesInquiryUnit Price: $1 /KG EXWCAS No.: 374633-32-6Grade: Industrial GradeContent: 99%
Learn More Other Chemicals
-
3-(3-CHLOROPROPYLCARBAMOYL)BENZENEBORONIC ACID
874288-10-5
-
3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester
58584-86-4
-
(+)-Mesembrenone
468-54-2
-
1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-, hydrochloride (1:1) Formula
230615-52-8
-
(4-acetyloxyphenyl)-(4-acetyloxyphenyl)imino-oxidoazanium Formula
79030-44-7
-
1-(4-Methoxy-phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde Formula
347331-30-0
-
2,2'-DIAMINODIPHENYL SULFIDE Structure
5873-51-8
-
AC-ARG-PHE-MET-TRP-MET-ARG-NH2 Structure
152274-65-2
-
What is 1,1-Dimethylethyl 2-bromo-2-methylpropanoate
23877-12-5
-
What is 1,3-Dichloro-2,4-difluorobenzene
36556-37-3
2-Chloro-3-fluoro-6-methylpyridine
SDSRequest for Quotation