Clobenpropit
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Clobenpropit
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CAS No:
145231-45-4
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Formula:
C14H17ClN4S
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Chemical Name:
Clobenpropit
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Synonyms:
Carbamimidothioic acid,N-[(4-chlorophenyl)methyl]-,3-(1H-imidazol-5-yl)propyl ester;Carbamimidothioic acid,[(4-chlorophenyl)methyl]-,3-(1H-imidazol-4-yl)propyl ester;VUF 9153;Clobenpropit
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CAS No:
Description
ChEBI: An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA
Clobenpropit dihydrobromide is a hydrobromide salt obtained by reaction of clobenpropit with two equivalents of hydrobromic acid. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. It has a role as a H4-receptor agonist and a H3-receptor antagonist. It contains a clobenpropit(2+).
Characteristics
89.86000
5.86030
white solid
1.31g/cm3
551.3ºC at 760mmHg
287.2ºC
1.645
H2O: >20 mg/mL
2-8°C
Clobenpropit Use and Manufacturing
An extremely potent histamine H 3 antagonist/inverse agonist (pA 2 =9.93). Also displays partial agonist activity at H 4 receptors; induces eosinophil shape change with an EC 50 of 3 nM. Also available as part of the Histamine H 3 Receptor Tocriset™ .