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Clonixin

Clonixin structure

CAS No:
17737-65-4
Formula:
C13H11ClN2O2
Chemical Name:
Clonixin
Synonyms:
3-Pyridinecarboxylic acid,2-[(3-chloro-2-methylphenyl)amino]-;Nicotinic acid,2-(3-chloro-o-toluidino)-;2-[(3-Chloro-2-methylphenyl)amino]-3-pyridinecarboxylic acid;2-(3-Chloro-2-methylanilino)nicotinic acid;Clonixin;Chlonixin;2-(2-Methyl-3-chloroanilino)nicotinic acid;2-(2′-Methyl-3′-chloro)-anilinonicotinic acid;Sch 10304;Clonixic acid;Clonixine;2-(3-Chloro-2-methylanilino)-3-pyridinecarboxylic acid;CBA 93626;NSC 335505
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a (2-methyl-3-chlorophenyl)amino group. Used (as its lysine salt) for treatment of renal colic, muscular pain and moderately severe migraine attacks.

Clonixin is a pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a (2-methyl-3-chlorophenyl)amino group. Used (as its lysine salt) for treatment of renal colic, muscular pain and moderately severe migraine attacks. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a platelet aggregation inhibitor, a vasodilator agent, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and a lipoxygenase inhibitor. It is a pyridinemonocarboxylic acid, an aminopyridine and an organochlorine compound. It derives from a nicotinic acid. It is a conjugate acid of a clonixin(1-).|Clonixin is a non-steroidal anti-inflammatory drug.|Anti-inflammatory analgesic.

Clonixin Basic Attributes

Molecular Weight：

262.69

Exact Mass：

262.69

EC Number：

241-730-1

UNII：

V7DXN0M42R

NSC Number：

335505

DSSTox ID：

DTXSID2046121

HScode：

2933399090

Characteristics

PSA：

62.2

XLogP3：

3.8

Appearance：

white to beige

Density：

1.3230 (rough estimate)

Melting Point：

234 °C

Boiling Point：

410.2±45.0 °C(Predicted)

Flash Point：

201.9±28.7 °C

Refractive Index：

1.5270 (estimate)

Water Solubility：

DMSO: soluble15mg/mL, clear

Storage Conditions：

room temp

Vapor Pressure：

1.83E-07mmHg at 25°C

Toxicity：

LD50 in male mice, rats (mg/kg): 415, 335 orally; 198, 148 i.p.; 296, 325 s.c. (Tanaka)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

36/37

RTECS Number：

QT0960000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 47 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.

Pharmacology：

Clonixin is a non-steroidal anti-inflammatory drug (NSAID) similar in structure to [DB00586]. It produces vasodilation and analgesia.

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Mechanism of Action：

The mechanism of clonixin does not appear to have been investigated on a molecular level. It is presumed to function similarly to other NSAIDs by inhibiting cycloxygenase enzymes 1 and 2 resulting in a reduction in prostaglandin production.

MeSH Entry Terms：

CBA 93626

Clonixin Use and Manufacturing

Analgesic.

Computed Properties

Molecular Weight:262.69
XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:262.0509053
Monoisotopic Mass:262.0509053
Topological Polar Surface Area:62.2
Heavy Atom Count:18
Complexity:301
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Clonixin

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

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clonixin17737-65-4

CAS No.: 17737-65-4

Grade: Pharmaceutical Grade

Content: 99%

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