2-Chloroethyl 1-(methylsulfonyl)methanesulfonate
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2-Chloroethyl 1-(methylsulfonyl)methanesulfonate
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CAS No:
88343-72-0
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Formula:
C4H9ClO5S2
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Chemical Name:
2-Chloroethyl 1-(methylsulfonyl)methanesulfonate
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Synonyms:
Methanesulfonic acid,1-(methylsulfonyl)-,2-chloroethyl ester;Methanesulfonic acid,(methylsulfonyl)-,2-chloroethyl ester;2-Chloroethyl 1-(methylsulfonyl)methanesulfonate;NSC 338947;Chlorethyl SOSO;Clomesone;2-Chloroethyl methanesulfonylmethanesulfonate;2-Chloroethyl methylsulfonylmethanesulfonate
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CAS No:
Description
Clomesone is the 2-chloroethyl ester of (methylsulfonyl) methanesulfonic acid with potential antineoplastic effects. Acting as a chloroethylating agent, clomesone induces the formation of DNA interstrand crosslinks in some cell lines, and exhibits antitumor activity in some animal models. Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)
2-Chloroethyl 1-(methylsulfonyl)methanesulfonate Basic Attributes
236.695
236.69
2J031W0YZI
338947
DTXSID10236979
C28888
Safety Information
Bulk: Clomesone is stable at room temperature in light or dark conditions but is unstable when stored at 50 °C in both light and dark conditions. Solution: The t90 of an aqueous solution is 207 minutes.
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
2-chloroethyl-(methylsulfonyl)methanesulfonate
Computed Properties
Molecular Weight:236.7
XLogP3:-0.3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:235.9579934
Monoisotopic Mass:235.9579934
Topological Polar Surface Area:94.3
Heavy Atom Count:12
Complexity:304
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloroethyl 1-(methylsulfonyl)methanesulfonate
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