Coformycin
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Coformycin
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CAS No:
11033-22-0
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Formula:
C11H16N4O5
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Chemical Name:
Coformycin
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Synonyms:
Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-β-D-ribofuranosyl-,(8R)-;Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-β-D-ribofuranosyl-,(R)-;(8R)-3,4,7,8-Tetrahydro-3-β-D-ribofuranosylimidazo[4,5-d][1,3]diazepin-8-ol;Coformycin;NSC 277817
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CAS No:
Description
ChEBI: An N-glycosyl in which (8R)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol is attached to ribofuranose via a beta-N3-glycosidic bond. compound The parent of the class of coformycins.
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.
Drug Information
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)
Coformycin
Computed Properties
Molecular Weight:284.27
XLogP3:-3.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:284.11206962
Monoisotopic Mass:284.11206962
Topological Polar Surface Area:132
Heavy Atom Count:20
Complexity:384
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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