Norelgestromin
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Norelgestromin
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CAS No:
53016-31-2
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Formula:
C21H29NO2
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Chemical Name:
Norelgestromin
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Synonyms:
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,oxime,(17α)-;D-Norgestrel 3-oxime;18-Methylnorethindrone oxime;17-Deacetylnorgestimate;Levonorgestrel 3-oxime;Norplant 3-oxime;Norelgestromin;RWJ 10553;BRN 4202099;Levonorgestrel oxime;d-(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime;17-Deacylnorgestimate
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CAS No:
Description
Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen.
Norelgestromin is a drug used in contraception. Norelgestromin is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.|Norelgestromin is a Progestin.
Safety Information
NONH for all modes of transport
|Danger|H302 (89.47%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 19 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Norelgestromin is used for contraception and menopausal hormonal therapy. Norelgestromin may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy.|Female contraception.Evra is intended for women of fertile age. The safety and efficacy has been established in women aged 18 to 45 years.
Norelgestromin is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring. Norelgestromin, in combination with ethinyl estradiol inhibits ovulation by suppressing gonadotropins.
Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)
Norelgestromin inhibits estrone sulfatase, which converts sulfated steroid precursors to estrogen during pregnancy. Norgelgestromin/ethinylestradiol suppresses follicular development, induces changes to the endometrium, which decreases chances of implantation and thickens the cervical mucus, impeding sperm swimming into the uterus. It also has similar agonisting binding affinities as its parent compound, Norgestimate, for progesterone and estrogen receptors.
17-deacetylnorgestimate
Norelgestromin Use and Manufacturing
A metabolite of Norgestimate
Human drugs -> Evra -> EMA Drug Category|Sex hormones and modulators of the genital system -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:327.5
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:327.219829168
Monoisotopic Mass:327.219829168
Topological Polar Surface Area:52.8
Heavy Atom Count:24
Complexity:642
Defined Atom Stereocenter Count:6
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes