Zinc chromate

181.37400

179.84900

236-878-9

05F2837HUF

0811

3288|3077

DTXSID7047485

C45893

Yellow prisms|Lemon yellow powder

80.26000

-0.47770

Zinc chromate is an odorless yellow solid. Sinks in water. (USCG, 1999)

3.40 g/cm³

316 °C

Solubility in water: none

Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.

Odorless

... hexavalent chromium compounds are acidic

Solid yellow, molecular wt: 307.6 /Zinc chromate heptahydrate/|Strong oxidizing agent|Corrosive because of its oxidizing potency /chromate salts/

No rapid reaction with air. No rapid reaction with water.

Salts, Basic

Strong Oxidizing Agent

Oxidizing agents, such as ZINC CHROMATE, can react with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). The chemical reduction of materials in this group can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Explosive mixtures of inorganic oxidizing agents with reducing agents often persist unchanged for long periods if initiation is prevented. Such systems are typically mixtures of solids, but may involve any combination of physical states. Some inorganic oxidizing agents are salts of metals that are soluble in water; dissolution dilutes but does not nullify the oxidizing power of such materials. Organic compounds, in general, have some reducing power and can in principle react with compounds in this class. Actual reactivity varies greatly with the identity of the organic compound. Inorganic oxidizing agents can react violently with active metals, cyanides, esters, and thiocyanates.

III

9

UN 3087

R8

17-45-53

GB3290000

T; N

Well closed. Separated from food and feedstuffs, reducing agents and organic compounds. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

P201, P202, P260, P261, P264, P270, P271, P272, P280, P281, P301+P312, P302+P352, P304+P340, P308+P313, P311, P314, P321, P330, P333+P313, P363, P403+P233, P405, P501

H302

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D007, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Chromium/|SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|The following wastewater treatment technology has been investigated for chromium: Concentration process: Biological Treatment. /Chromium/|The following wastewater treatment technology has been investigated for chromium: Concentration process: Chemical Precipitation. /Chromium/|For more Disposal Methods (Complete) data for ZINC CHROMATE (14 total), please visit the HSDB record page.

An oxidizer; reacts with reducing agents, combustibles, organic materials.|Oxidizing agents, such as ZINC CHROMATE, can react with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). The chemical reduction of materials in this group can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Explosive mixtures of inorganic oxidizing agents with reducing agents often persist unchanged for long periods if initiation is prevented. Such systems are typically mixtures of solids, but may involve any combination of physical states. Some inorganic oxidizing agents are salts of metals that are soluble in water; dissolution dilutes but does not nullify the oxidizing power of such materials. Organic compounds, in general, have some reducing power and can in principle react with compounds in this class. Actual reactivity varies greatly with the identity of the organic compound. Inorganic oxidizing agents can react violently with active metals, cyanides, esters, and thiocyanates.|Combustible, organic, or other readily oxidizable materials (paper, wood, sulfur, aluminum, plastics, etc.); corrosive to metals. /Chromic acid and chromates/|Hydrazine is decomposed explosively by chromates and chromic anhydride. /Chromates/

USEPA; Ambient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079|USEPA; Ambient Water Quality Criteria Doc: Zinc (1987) EPA 440/5-87-003

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)|Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with reducing agents or organic materials.

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P272, P273, P280, P281, P301+P312, P302+P352, P308+P313, P321, P330, P333+P313, P363, P391, P405, and P501|Aggregated GHS information provided by 99 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Aggregated GHS information provided by 73 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P301+P312, P302+P352, P304+P340, P308+P313, P311, P314, P321, P330, P333+P313, P363, P391, P403+P233, P405, and P501|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P264, P270, P272, P280, P281, P285, P302+P352, P304+P341, P307+P311, P308+P313, P314, P321, P333+P313, P342+P311, P363, P405, and P501|P201, P202, P261, P272, P280, P281, P285, P302+P352, P304+P341, P308+P313, P321, P333+P313, P342+P311, P363, P405, and P501

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Suitable respirator (for dust); rubber gloves; chemical goggles or face shield (USCG, 1999)|Wear protective gloves and clothing to prevent any reasonable probabiliy of skin contact. Prevent skin contact. ... Contact lenses should not be worn when working with this chemical. Eye protection is included in the recommended respiratory protection. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.|Protective Clothing: Suitable respirator (for dust); rubber gloves; chemical goggles or face shield.|Impervious gloves, aprons, and footwear shall be worn at operations where solutions of chromium (VI) may contact the skin. Protective gloves shall be worn at operations where dry compounds of chromium (VI) are handled and may contact the skin. /Cr(VI)/|Protective clothing: Coveralls or other full-body protective clothing shall be worn in areas where there is occupational exposure to chromium (VI). Protective clothing shall be changed at least daily at the end of the shift and more frequently if it should become grossly contaminated. /Cr(VI)/|For more Personal Protective Equipment (PPE) (Complete) data for ZINC CHROMATE (11 total), please visit the HSDB record page.

Nonflammable. Use agent suitable for surrounding fire.|From a secure, explosion-proof location, use water spray to cool exposed containers, If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position.|The only respirators recommended for firefighting are self-contained breathing apparatuses that have full face-pieces and are operated in a pressure-demand or other positive-pressure mode.|SMALL FIRE: Dry chemical, CO2 or water spray.|For more Fire Fighting Procedures (Complete) data for ZINC CHROMATE (7 total), please visit the HSDB record page.

Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.|As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.|Cr(VI) cmpd in waste sludge are completely removed by redn by carbon at 600 °C. /Chromium VI/|Persons not wearing protective equipment and clothing should be restricted from areas of spills until cleanup has been completed. If chromic acid or chromates are spilled, the following steps should be taken: 1. Ventilate area of spill. 2. Collect spilled material in the most convenient and safe manner and deposit in sealed containers for reclamation or for disposal in a secured sanitary landfill. Liquid containing chromic acid or chromates should be absorbed in vermiculite, dry sand, earth, or a similar material. /Chromic acid and chromates/|PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.|Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. /Chromic acid and cromates/|Work clothing that becomes wet or significantly contaminated should be removed and replaced. /Chromic acid and cromates; Chromium(II) compounds (as Cr); Chromium(III) compounds/|For more Preventive Measures (Complete) data for ZINC CHROMATE (14 total), please visit the HSDB record page.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Zinc chromate can irritate the skin, causing a rash or skin ulcers.|Chromic acid mist & chromate dusts may cause severe irritation of the nose, throat, bronchial tubes, and lung. /Chromic acid mist & chromate dusts/

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 mg/cu m. /Chromium metal and insoluble salts, as Cr/|Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 0.5 mg/cu m. /Chromium(II) compounds, as Cr/|Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 0.5 mg/cu m. /Chromium(III) compounds, as Cr/|Permissible Exposure Limit: Table Z-2 Acceptable Ceiling Concentration: 1 mg/10 cu m. /Chromic acid and chromates (as CrO3)/

Recommended Exposure Limit: 8-hour Time-Weighted Average: 0.5 mg Cr/cu m. /Chromium metal, chromium(II) and chromium(III) compounds/|Recommended Exposure Limit: 8-hour Time-Weighted Average: 0.0002 mg Cr(VI)/cu m. NIOSH considers all Cr(VI) compounds (including chromic acid, tert-butyl chromate, zinc chromate, and chromyl chloride) to be potential occupational carcinogens. /All hexavalent chromium (Cr(VI) compounds/|NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Chromic acid and chromates/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Vacuum spilled material with specialist equipment. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Well closed. Separated from food and feedstuffs, reducing agents and organic compounds. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract.

The substance may have effects on the blood, bone marrow, central nervous system, peripheral nervous system and kidneys. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum. Repeated or prolonged contact may cause skin sensitization. This substance is carcinogenic to humans. May cause toxicity to human reproduction or development.

NO contact with incompatible materials: See Chemical Dangers

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or eye protection in combination with breathing protection if powder.

... Substances for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, from ambient air exposure to the substance. Chromium is included on this list. /Chromium/|Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Chromium compounds is included on this list. /Chromium compounds/

D007; A waste containing chromium may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Chromium/

D007; A solid waste containing chromium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Chromium/

IDENTIFICATION AND USE: Zinc chromate is a lemon-yellow powder. Zinc chromates are employed primarily in priming paints used for metals, for which they provide resistance against corrosion. HUMAN EXPOSURE AND TOXICITY: Development of dermatitis from exposure to zinc chromate has been reported, but such instances are rare. An outbreak of hand dermatitis was reported amongst employees working on a new assembly line of an electronics factory. Twenty-four out of 41 employees had signs of irritant contact dermatitis. The fingertips and the dorsal parts of the hands were especially affected. In 1975, five manufacturers of chromate pigment (including zinc chromate) in Japan were examined in a study of the carcinogenicity of chromates. None of the results showed statistically significant differences that would suggest an excess risk for malignant neoplasms, particularly lung cancer, among workers engaged in the manufacture of chromate pigment in Japan. However, several other studies of workers exposed to chromium compounds have suggested an increased incidence of respiratory cancers. Lead and zinc chromates were among the chromium compounds implicated. A study was done in a pigment plant in Newark, New Jersey, USA, which utilized both of these compounds. Observed deaths from each cause were compared with expected deaths. A statistically significant relative risk of 1.6 for lung cancer was found. An increased incidence of lung cancer was also evident. A small cohort of Norwegian male workers were studied from a company which produced zinc chromate paint. They found 3 cases of bronchial carcinoma (in workers aged 41, 51, and 59) where only 0.079 was expected for the total period of observation. The three cases had six to nine years of exposure to zinc chromate dust levels of approximately 0.5 to 1.5 mg Cr/cu m. Two of the three carcinomas were found in smokers. There was also one case of nasal cancer in a man with a total of 3 months of exposure. In a study of zinc chromate spray painters and electroplaters at two large aircraft maintenance facilities, the relative excess for respiratory cancer among spray painters (21 observed vs 11.4 expected) was statistically significant. The ability of chronic exposure to zinc chromate to induce numerical chromosome instability was tested in human lung fibroblasts. The study found no increase in aneuploidy after a 24 hr exposure to zinc chromate, but with more chronic exposures, zinc chromate induced concentration- and time-dependent increases in aneuploidy in the form of hypodiploidy, hyperdiploidy, and tetraploidy. Zinc chromate also induced centrosome amplification in a concentration- and time-dependent manner in both interphase and mitotic cells after chronic exposure, producing cells with centriolar defects. Furthermore, chronic exposure to zinc chromate induced concentration- and time-dependent increases in spindle assembly checkpoint bypass with increases in centromere spreading, premature centromere division, and premature anaphase. All together, these data indicate that zinc chromate can induce chromosome instability after prolonged exposures. In human brochial cells zinc chromate was more clastogenic than all other chromium compounds. ANIMAL STUDIES: Six intratracheal injections of zinc chromate were given at 6 week intervals to 62 mice, which were observed until their death. No pulmonary carcinomas were found; pulmonary adenomas occurred in 31/62 exposed, in 7/18 untreated control and in 0/2 zinc carbonate-treated control animals. Pulmonary adenomas occurred in 1 of 21 guinea pigs that were given 6 intratracheal instillations of zinc chromate, no pulmonary adenomas occurred in controls. Chromium containing materials were examined for carcinogenic activity in a two-year study using an intrabronchial pellet implantation system whereby pellets loaded with test material were surgically implanted into the lower left bronchus of rats. Zinc chromate resulted in bronchial carcinomas in 5/100 rats tested. A further zinc chromate group produced bronchial carcinomas in 3/100, which was not statistically significant. Zinc chromate induced forward mutations to 8-azaguanine resistance in Chinese hamster V79/4 cells. Deaths in cattle believed to have had access to zinc chromate paste have been recorded in New Zealand. A daily dose of 30-40 mg/kg body weight produced severe chronic poisoning in young calves within one month. The acute lethal dose for adult cattle is about 20 times this amount. The outstanding clinical feature of the condition produced was profuse scouring, leading in chronic cases to severe dehydration and a low terminal blood pressure. Changes in the alimentary tract were the most marked post mortem finding. In acute poisoning, there was severe congestion and inflammation throughout the intestines and sloughing of the gastric mucous membranes. In chronic poisoning, congestion and inflammation were present only in the stomach (the rumen and abomasum in particular) showing severe ulceration and near perforation.

Food chain concentration potential (zinc chromate): Both chromium and zinc are concentrated by some organisms but are not considered to be bioconcentrative in a spill situation(1).

According to the 2012 TSCA Inventory Update Reporting data, 1 reporting facility estimated the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of zinc chromate (13530-65-9) in the United States as 100-499 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 58,924 workers (4,190 of these are female) were potentially exposed to zinc chromate in the US(1). Occupational exposure to zinc chromate may occur through inhalation of dust and particulates and dermal contact with this compound at workplaces where zinc chromate is produced or used(2).|Chromium pigment workers are exposed primarily to lead chromate(VI), although in the past they were also exposed to zinc chromate(VI) and to its raw material, sodium dichromate. The total mean amount of dust in a zinc chromate-producing plant ranged from 1.2-9.8 mg/cu m, with a maximum of 13.6 mg/cu m for workers filling sacks; lower exposure was found for workers mixing raw materials (2.9-6 mg/cu m) and for foremen (1.9-3.8 mg/cu m). The concentration of chromate (as Cr) in the air varied from 0.01-1.35 mg/cu m

... Chromates(VI) are absorbed /from the gastrointestinal tract/ at a rate of 3-6% in rats. ... Zinc chromate(VI) was absorbed quickly in rats exposed to known atmospheric concentrations (6.3-10.7 mg/cu m, equivalent to 1.3-2.2 mg/cu m chromium) in an inhalation chamber: a 5 fold increase in the blood chromium level was observed after 100 minutes of inhalation exposure, and this level increased at a similar rate during the next 150 minutes. Elimination from blood was slow: the blood chromium level fell by less than 50% during the first 3 days after exposure; and after 18 and 37 days, respectively, 20% and 9% of the initial concentration remained. Excretion occurred mainly via the urine.|Two groups of rats were exposed in the same zinc chromate dust cloud, 1 in open wire cages & the other in fiber glass tubes. The chromium excretion during the following 2.5 days was 8.4 times higher in feces & 5.5 times higher in urine in the animals exposed in cages compared with those exposed in tubes.|(51)Cr-labelled sodium, zinc and lead chromates were studied. Sodium chromate and the less soluble zinc chromate were absorbed by the blood, resulting in increased urinary excretion of chromium. ... The less water soluble the chromate, the higher was its elimination via the feces. Absorbed chromium was retained in the spleen and bone marrow in all three cases, and also in the liver and kidneys in the case of sodium chromate. Chromium levels in blood and urine are not indicative of inhalation exposure to insoluble chromates.|The relative significance of dust ingestion during and after short-term inhalation exposure to a zinc chromate aerosol has been studied. Two groups of rats were exposed in the same dust cloud, one in open wire cages and the other in fiber glass tubes. The chromium excretion during the following 2 1/2 days was 8.4 times higher in feces and 5.5 times higher in urine in the animals exposed in cages, compared with those exposed in tubes.|Studies on absorption and excretion of chromium in the rat exposed to known atmospheric concentrations of zinc chromate in an inhalation chamber and the influence of diurnal variations in physical activity have been carried out. Chromium analyses were performed on samples of blood, urine and feces using a method for determining chromium in small samples of biological material based on flameless atomic absorption spectrometry. Zinc chromate is absorbed quickly during exposure and excreted mainly via urine. An accumulation of chromium in blood was observed, followed by a slow elimination. It is suggested that chromium from zinc chromate enters the blood in the hexavalent state.

Inhalation of dust causes irritation of nose and throat. Ingestion can cause irritation or corrosion of the alimentary tract, circulatory collapse, and toxic nephritis. Contact with eyes or skin causes irritation. (USCG, 1999)|Carcinogens

INHALATION: move to fresh air; if exposure has been severe, get medical attention. INGESTION: induce vomiting, followed by prompt and complete gastric lavage, catharsis, and demulcents. EYES: flush with water. SKIN: wash thoroughly with soap and water. (USCG, 1999)

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/|/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Inorganic acids and related compounds/|For more Antidote and Emergency Treatment (Complete) data for ZINC CHROMATE (6 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ Development of dermatitis from exposure to zinc chromate and sulfate has been reported, but such instances are rare.|/CASE REPORTS/ An outbreak of hand dermatitis is reported amongst employees working on a new assembly line of an electronics factory. Twenty-four out of 41 employees had signs of irritant contact dermatitis. The fingertips and the dorsal parts of the hands were especially affected. Mechanical factors in combination with zinc-chromium compounds from galvanized steel seemed to be responsible for the dermatitis and the dry skin. The use of an emollient solved the problem. /Zinc chromium compounds/|/EPIDEMIOLOGY STUDIES/ In 1975, five manufacturers of chromate pigment in Japan were examined in a study of the carcinogenicity of chromates. These companies were producing lead chromate, zinc chromate, molybdate orange and/or strontium chromate. The current study covers a cohort of 666 workers involved in the manufacture of chromate pigment for at least 1 year between 1950 and 1975. The workers were followed up for 15-40 years, until 1989. Many previous reports have found an excess lung cancer risk among workers involved in the manufacture of chromate pigments and chromate chemicals. In the current study, subjects were classified on the basis of years worked, years of observation, characteristics of company, type of work engaged in for the longest period of time, and involvement in the manufacture of zinc chromate. Mortality was compared with that of all Japanese males by means of the person-year method. The route of exposure was primarily inhalation through the respiratory system. None of the results showed statistically significant differences that would suggest an excess risk for malignant neoplasms, particularly lung cancer, among workers engaged in the manufacture of chromate pigment in Japan.|/EPIDEMIOLOGY STUDIES/ Epidemiologic studies on chromate workers are considered with special reference to the valency of chromium compounds, carcinogenic potency, and water solubility. It is assumed that all hexavalent chromium compounds are carcinogenic to humans when inhaled but that there is no evidence that trivalent compounds are carcinogenic. It is suggested that zinc chromate is a highly potent carcinogen and also that calcium chromate may be carcinogenic. There are indications that chromates of low water solubility may be less potent carcinogens than compounds of greater solubility. Evidence is also presented for possible interactions with smoking and other factors involved in work-related cancers.|For more Human Toxicity Excerpts (Complete) data for ZINC CHROMATE (23 total), please visit the HSDB record page.

zinc chromate

The substance can be absorbed into the body by inhalation of dust and by ingestion.

Cough. See Effects of long-term or repeated exposure.

Redness.

Redness.

Zinc chromate is available commercially in the USA only in the form of basic zinc chromate. A typical analysis of basic zinc chromates is ZnO, 71.0% by weight; CrO3, 17.0%; combined water, 10.0%; moisture, 1.5%; and total water-soluble salts, 0.2%.|Micronized grades, pigment grade

All other basic inorganic chemical manufacturing|Chromic acid (H2CrO4), zinc salt (1:1): ACTIVE|R - indicates a substance that is the subject of a TSCA section 6 risk management rule.|The term 'zinc chromate' is a generic term for a series of commercial products with three kinds of molecular structure: (i) 'zinc chromate' type (like ZnCr04); (ii) 'basic zinc chromate' type (like zinc tetrahydroxychromate (ZnCr04.4Zn(OH)2); and (iii) '(basic) zinc potassium chromate' type (like 3ZnCr04.Zn(OH)2.K2Cr04' 2H20). Several different commercial 'zinc chromates' are also referred to as 'zinc yellow'.

Zinc, zinc oxide, lead, the 4 known zinc chromates, & rhombic & monoclinic lead chromate were identified in 0.3-0.5 mg paint samples by x-ray diffractometry. The zinc chromates were identifiable at 7.0-9.3 angstroms. The method could be used to identify, but not to quantitate zinc chromates on filters of air samples from areas used for spray painting.

Health Hazards -> Carcinogens