DPCPX
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DPCPX
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CAS No:
102146-07-6
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Formula:
C16H24N4O2
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Chemical Name:
DPCPX
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Synonyms:
1H-Purine-2,6-dione,8-cyclopentyl-3,9-dihydro-1,3-dipropyl-;1H-Purine-2,6-dione,8-cyclopentyl-3,7-dihydro-1,3-dipropyl-;8-Cyclopentyl-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione;PD 116948;8-Cyclopentyl-1,3-dipropylxanthine;1,3-Dipropyl-8-cyclopentylxanthine;DPCPX;CPX
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CAS No:
Description
White SolidChEBI: An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
DPCPX is an oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group. It has a role as an adenosine A1 receptor antagonist and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. It derives from a 7H-xanthine.|CPX has been used in trials studying the treatment of Cystic Fibrosis.
Characteristics
69.3
2.36390
white solid
1.195±0.06 g/cm3(Predicted)
199-200 °C @ Solvent: Dimethylformamide, Water
535.1±42.0 °C(Predicted)
277.4ºC
1.564
DMSO: >10 mg/mL
Store at RT
1.59E-11mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
Xi
Store tightly sealed at RT; Solutions at 4 deg C for several days
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Compounds that bind to and block the stimulation of ADENOSINE A1 RECEPTORS. (See all compounds classified as Adenosine A1 Receptor Antagonists.)
1,3-dipropyl-8-cyclopentylxanthine
DPCPX Use and Manufacturing
DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes.Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist
Computed Properties
Molecular Weight:304.39
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:304.18992602
Monoisotopic Mass:304.18992602
Topological Polar Surface Area:69.3
Heavy Atom Count:22
Complexity:436
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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