7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
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![7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/8e44598b5cab4bfc873aa23b1a13c87c.png "7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine")
7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
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CAS No:
213743-31-8
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Formula:
C23H22N4O
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Chemical Name:
7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
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Synonyms:
7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-cyclopentyl-5-(4-phenoxyphenyl)-;7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;RK 24466;7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine;KIN 001-51
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CAS No:
Description
RK-24466 is a member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively). It has a role as a geroprotector and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a primary amino compound, a pyrrolopyrimidine, an aromatic amine, an aromatic ether and a member of cyclopentanes.
7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine Basic Attributes
370.454
370.45
Characteristics
66
4.6
white
1.30±0.1 g/cm3(Predicted)
605.1°C at 760 mmHg
DMSO: 17 mg/mL at ≤60 °C, soluble
2-8°C
Computed Properties
Molecular Weight:370.4
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:370.17936134
Monoisotopic Mass:370.17936134
Topological Polar Surface Area:66
Heavy Atom Count:28
Complexity:497
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
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