(-)-2-Amino-5-phosphonovaleric acid
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(-)-2-Amino-5-phosphonovaleric acid
structure -
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CAS No:
79055-68-8
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Formula:
C5H12NO5P
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Chemical Name:
(-)-2-Amino-5-phosphonovaleric acid
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Synonyms:
D-Norvaline,5-phosphono-;5-Phosphono-D-norvaline;D-2-Amino-5-phosphonovaleric acid;(-)-2-Amino-5-phosphonovaleric acid;(-)-2-Amino-5-phosphonopentanoic acid;D-(-)-2-Amino-5-phosphonopentanoic acid;D-2-Amino-5-phosphonopentanoic acid;D-Aminophosphonovaleric acid;(R)-2-Amino-5-phosphonopentanoic acid;D-AP-5;(R)-AP-5;(R)-2-Amino-5-phosphonopentanoic acid;(2R)-2-Amino-5-phosphonopentanoic acid
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CAS No:
Description
D-AP5 is a NMDA receptor antagonist.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Characteristics
121
-2.32
white fine crystalline powder
1.5±0.1 g/cm3
245-246 °C @ Solvent: Ethanol, Water
482.1±55.0 °C at 760 mmHg
245.4±31.5 °C
1.536
Store at RT
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
RD2513000
Xi
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)
2 Amino 5 phosphonopentanoate
Computed Properties
Molecular Weight:197.13
XLogP3:-5.3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:197.04530948
Monoisotopic Mass:197.04530948
Topological Polar Surface Area:121
Heavy Atom Count:12
Complexity:200
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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(-)-2-Amino-5-phosphonovaleric acid
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