14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate
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14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate
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CAS No:
76958-99-1
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Formula:
C28H35O10.K
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Chemical Name:
14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate
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Synonyms:
14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate;DDHADS;Kalii Dehydrographolidi Succinas;HY-N0677A;C28H35O10.K;8093AH;CCG-270096;CS-0022561
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CAS No:
Computed Properties
Molecular Weight:570.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:13
Exact Mass:570.18672879
Monoisotopic Mass:570.18672879
Topological Polar Surface Area:156
Heavy Atom Count:39
Complexity:1060
Defined Atom Stereocenter Count:5
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
1. It has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins; 2. It has a good anti-inflammatory effect, can counteract the increased permeability of capillary walls caused by xylene or histamine, and has a significant antagonistic effect on adrenaline-induced acute pulmonary edema; 3. It has a certain sedative effect, can shorten the sleep latency of mice caused by sodium pentobarbital, and prolong their sleep time; 4. It can promote the adrenal cortex function of rats and increase the body's emergency response to pathogen infection; 5. It has a certain inactivation effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type Ⅲ, type Ⅳ, enterosyncytial virus and respiratory syncytial virus (RSV). In addition, its antiviral effect may be related to promoting the phagocytosis of neutrophils and macrophages and increasing the content of lysozyme in the blood.
Registered Holders
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Lanxiha Sanlian Pharmaceutical Co., Ltd.
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China
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Jilin Aodong--Taonan Pharnalentical Company Ltd
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China
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Sichuan Wenlong Pharmaceutical Co., Ltd.
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China
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14-deoxy-11,12-didehydroandrographolide 3,19-disuccinate
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