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3′-Fluorothymidine

3′-Fluorothymidine structure

CAS No:
25526-93-6
Formula:
C10H13FN2O4
Chemical Name:
3′-Fluorothymidine
Synonyms:
Thymidine,3′-deoxy-3′-fluoro-;3′-Deoxy-3′-fluorothymidine;1-(3′-Deoxy-3′-fluoro-β-D-pentofuranosyl)thymine;3′-Fluorodeoxythymidine;3′-Fluorothymidine;3′-Fluoro-3′-deoxythymidine;FLT;Alovudine;CL 184824;NSC 140025;MIV 310;3′-Fluoro-2′,3′-dideoxythymidine;25515-31-5
Categories:
Biochemical Engineering > Saccharides

Description

3'-Fluoro-3'-deoxythymidine (Alovudine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer[1].

Alovudine is a pyrimidine 2',3'-dideoxyribonucleoside.|Alovudine is a nucleoside reverse transcriptase inhibitor analog of thymidine.

3′-Fluorothymidine Basic Attributes

Molecular Weight：

244.22

Exact Mass：

244.22

UNII：

PG53R0DWDQ

DSSTox ID：

DTXSID4046579

NCI Thesaurus Code：

C65226

HScode：

29349990

Characteristics

PSA：

84.32000

XLogP3：

-0.52

Appearance：

Colourless solid

Density：

1.4±0.1 g/cm3

Melting Point：

176-178 °C

Refractive Index：

1.565

Storage Conditions：

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

wgk germany：

safety instructions：

24/25

RTECS Number：

XP2073000

Drug Information

Drug Indication：

Investigated for use/treatment in HIV infection.

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

MeSH Entry Terms：

(18)FLT cpd

3′-Fluorothymidine Use and Manufacturing

An antiviral agent

Computed Properties

Molecular Weight:244.22
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:244.08593506
Monoisotopic Mass:244.08593506
Topological Polar Surface Area:78.9
Heavy Atom Count:17
Complexity:385
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3′-Fluorothymidine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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3-Deoxy-3-fluorothymidine

CAS No.: 25526-93-6

Content: 99.00%

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

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Manufactory Supplier of fine chemicals,pharmaceutical materials

3'-Deoxy-3'-fluorothymidine

CAS No.: 25526-93-6

Grade: industrial Grade

Content: 98%

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Guide of 3′-Fluorothymidine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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3′-Fluorothymidine

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