5,7-dichloro-1,6-naphthyridine
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5,7-dichloro-1,6-naphthyridine
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CAS No:
337958-60-8
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Formula:
C8H4Cl2N2
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Chemical Name:
5,7-dichloro-1,6-naphthyridine
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Synonyms:
5,7-dichloro-1,6-naphthyridine;5,7-Dichloro-1,6-naphthyridine, 97%;PubChem14653;SCHEMBL2588073;5,7-dichloro-1,6-napthyridine;CTK4H1262;DTXSID10480354;1,6-Naphthyridine,5,7-dichloro-;BCP14732;ANW-48953
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CAS No:
5,7-dichloro-1,6-naphthyridine Basic Attributes
199.04
197.975159
1533716-785-6
DTXSID10480354
2933990090
Characteristics
25.8
3
White to yellow Crystalline Powder
1.5±0.1 g/cm3
344.5°C at 760 mmHg
192.9±12.1 °C
1.671
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5,7-dichloro-1,6-naphthyridine Use and Manufacturing
Intermediate 7: 5, 7-Dichloro-1, 6-naphthyridine[0384]N-(2, 6-Dichloro-4-pyridinyl)-2, 2-dimethylpropanamide (1 g, 4.05 mmol) was taken up in THF (10 ml) under nitrogen and cooled to n-Butyl lithium (4.05 ml, 10.12 mmol, 2.5M solution in hexanes) was added over 30 min keeping the temperature below −60° C. and then stirred at below −70° C. for 1 h. (2E)-3-(dimethylamino)-2-propenal (0.607 ml, 6.07 mmol) in THF (2 ml) was added over 30 min keeping the temperature below −60° C. The reaction was stirred at below −70° C. for 20 min and then allowed to warm to room temperature. LCMS showed that no starting material remained so the reaction was quenched with 5M HCl (5 ml) and refluxed overnight. LCMS showed good conversion to product so the reaction was cooled to room temperature. The reaction mixture was basified with solid K
Computed Properties
Molecular Weight:199.03
XLogP3:3
Hydrogen Bond Acceptor Count:2
Exact Mass:197.9751535
Monoisotopic Mass:197.9751535
Topological Polar Surface Area:25.8
Heavy Atom Count:12
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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