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3,5-dichloropicolinaMide

3,5-dichloropicolinaMide structure

CAS No:
5468-71-3
Formula:
C6H4Cl2N2O
Chemical Name:
3,5-dichloropicolinaMide
Synonyms:
3,5-dichloropicolinaMide;3,5-Dichloro-2-pyridinecarboxamide;NSC 15050;3,5-dichloropicoliMide;3,5-Dichloropyridine-2-carboxamide
Categories:
Chemical Reagents > Organic Reagents

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3,5-dichloropicolinaMide Basic Attributes

Molecular Weight：

191.01476

Exact Mass：

189.970062

NSC Number：

15050

DSSTox ID：

DTXSID40279995

HScode：

2933399090

Characteristics

PSA：

XLogP3：

1.3

Appearance：

Off-white Powder

Density：

1.5±0.1 g/cm3

Boiling Point：

283.5±40.0℃ (760 Torr)

Flash Point：

125.3±27.3℃

Refractive Index：

1.604

3,5-dichloropicolinaMide Use and Manufacturing

General procedure: A 500-mL RBF was charged with 5-chloro-2-pyridinecarboxylic acid (Ark Pharm, 10.00 g, 63.5 mmol) and thionyl chloride (Aldrich, 100 ml, 1371 mmol). A catalytic amount of DMF (0.2 ml) was added and the reaction mixture was heated to 80 C under Argon atmosphere for 4 hours. The reaction mixture was cooled to RT and concentrated under reduced pressure. The residue was diluted with DCM (100 ml) and added slowly to a stirred solution of ammonium hydroxide (131 ml, 3364 mmol) at 0 C. After completed addition, the reaction mixture was allowed to stir an additional 10 min. The reaction mixture was concentrated under reduced pressure and the precipitate was filtered off. The solid was washed with water and dried to give the title compound (8.686 g, 55.5 mmol, 87 % yield) as an off-white solid. MS m/z=157 [M+H]+. Calculated for C6H5C1N20: 156Example 1Preparation of 6-chloro-1-isopropyl-1H-imidazo[4, 5-b]pyridin-2-ol; Example 1(a) 5-chloro-3-(isopropylamino)picolinamide:

Computed Properties

Molecular Weight:191.01
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:189.9700681
Monoisotopic Mass:189.9700681
Topological Polar Surface Area:56
Heavy Atom Count:11
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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5468-71-3 3,5-dichloropyridine-2-carboxamide

CAS No.: 5468-71-3

Grade: Industrial Grade

Content: 95%

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