3,5-dichloropicolinaMide
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3,5-dichloropicolinaMide
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CAS No:
5468-71-3
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Formula:
C6H4Cl2N2O
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Chemical Name:
3,5-dichloropicolinaMide
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Synonyms:
3,5-dichloropicolinaMide;3,5-Dichloro-2-pyridinecarboxamide;NSC 15050;3,5-dichloropicoliMide;3,5-Dichloropyridine-2-carboxamide
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CAS No:
3,5-dichloropicolinaMide Use and Manufacturing
General procedure: A 500-mL RBF was charged with 5-chloro-2-pyridinecarboxylic acid (Ark Pharm, 10.00 g, 63.5 mmol) and thionyl chloride (Aldrich, 100 ml, 1371 mmol). A catalytic amount of DMF (0.2 ml) was added and the reaction mixture was heated to 80 C under Argon atmosphere for 4 hours. The reaction mixture was cooled to RT and concentrated under reduced pressure. The residue was diluted with DCM (100 ml) and added slowly to a stirred solution of ammonium hydroxide (131 ml, 3364 mmol) at 0 C. After completed addition, the reaction mixture was allowed to stir an additional 10 min. The reaction mixture was concentrated under reduced pressure and the precipitate was filtered off. The solid was washed with water and dried to give the title compound (8.686 g, 55.5 mmol, 87 % yield) as an off-white solid. MS m/z=157 [M+H]+. Calculated for C6H5C1N20: 156Example 1Preparation of 6-chloro-1-isopropyl-1H-imidazo[4, 5-b]pyridin-2-ol; Example 1(a) 5-chloro-3-(isopropylamino)picolinamide:
Computed Properties
Molecular Weight:191.01
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:189.9700681
Monoisotopic Mass:189.9700681
Topological Polar Surface Area:56
Heavy Atom Count:11
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 5468-71-3Grade: Industrial GradeContent: 95%
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