4,6-Dibromodibenzofuran

Add 32.4g (100mmol) 4, 6-dibromodibenzothiophene and 112.8g (300mmol) 2-formylbenzeneboronic acid to a freshly dried 3000mL two-necked bottle, add 62.1g (450mmol) under nitrogen protection Anhydrous potassium carbonate, 6.9 g (6 mmol) of tetratriphenylphosphine palladium, and 225 mL of water and 1500 mL of 1, 4-dioxane. After the reaction, the temperature was lowered to room temperature, and the solvent of the reaction system was distilled off under reduced pressure. The crude product was dissolved in 500 mL of dichloromethane and washed with a large amount of water. The organic phase was dried over anhydrous sodium sulfate and concentrated. Dichloromethane: petroleum ether = 1: 1 was used as the eluent for column chromatography to obtain 30 g of off-white solid with a yield of 80%.i. Weigh 32.6 mg of 4, 6-dibromobenzofuran and 121 mg of the compound of formula (8) and add it to a mixed solvent containing toluene and ethanol (the volume ratio is toluene: ethanol = 12: 1), Protected by nitrogen, heated to 80 C, and reacted for 20 minutes.Then add 2mg of tris (dibenzylideneacetone) dipalladium, 13 mg of bis (2-diphenylphosphine) phenyl ether and 1 ml of potassium carbonate aqueous solution (2 mol / L), heated to 95 C, and reacted for 10 hours.Stop the reaction, extract, collect the organic phase, evaporate the organic solvent under reduced pressure to obtain the crude product, and purify by column chromatography to obtain the compound of formula (VII).The eluent was a mixed solvent of chloroform and n-hexane (the volume ratio was chloroform: n-hexane = 1: 2).In a round bottom flask, 20.0 g of dibenzo[b, d]furan-4-ylboronic acid, 33.8 g of

Molecular Weight:325.98
XLogP3:5
Hydrogen Bond Acceptor Count:1
Exact Mass:325.87649
Monoisotopic Mass:323.87854
Topological Polar Surface Area:13.1
Heavy Atom Count:15
Complexity:222
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes