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Piceatannol

Piceatannol structure

CAS No:
10083-24-6
Formula:
C14H12O4
Chemical Name:
Piceatannol
Synonyms:
1,2-Benzenediol,4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;3,3′,4,5′-Stilbenetetrol,(E)-;Piceatannol;1,2-Benzenediol,4-[2-(3,5-dihydroxyphenyl)ethenyl]-,(E)-;4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol;Astringenin;trans-3,3′,4,5′-Tetrahydroxystilbene;(E)-Piceatannol;trans-Piceatannol;21100-92-5
Categories:
Cosmetic Ingredient > Antioxidant Ingredient

Description

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppre

Solid

Piceatannol is a stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5. It has a role as a protein kinase inhibitor, a tyrosine kinase inhibitor, an antineoplastic agent, a plant metabolite, a hypoglycemic agent, an apoptosis inducer and a geroprotector. It is a stilbenol, a member of resorcinols, a member of catechols and a polyphenol. It derives from a hydride of a trans-stilbene.|Piceatannol is a polyhydroxylated stilbene extract from the seeds of Euphorbia lagascae, which inhibits protein tyrosine kinase Syk and induces apoptosis. (NCI)

Piceatannol Basic Attributes

Molecular Weight：

244.246

Exact Mass：

244.24

EC Number：

600-132-4

UNII：

6KS3LS0D4F

NSC Number：

622471|365798

DSSTox ID：

DTXSID6040587

NCI Thesaurus Code：

C1195

HScode：

2907299090

Characteristics

PSA：

80.9

XLogP3：

2.9

Appearance：

Solid

Density：

1.5±0.1 g/cm3

Melting Point：

215-217 °C

Boiling Point：

507.3ºC at 760 mmHg

Flash Point：

252.2±21.4 °C

Refractive Index：

1.801

Water Solubility：

H2O: 0.5 mg/mL

Storage Conditions：

2-8ºC

Vapor Pressure：

6.51E-11mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

Drug Information

MeSH Entry Terms：

3'-hydroxyresveratol

Piceatannol Use and Manufacturing

Use Classification：

Polyketides [PK] -> Aromatic polyketides [PK13] -> Diphenyl ethers, biphenyls, dibenzyls and stilbenes [PK1309]

Computed Properties

Molecular Weight:244.24
XLogP3:2.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:244.07355886
Monoisotopic Mass:244.07355886
Topological Polar Surface Area:80.9
Heavy Atom Count:18
Complexity:282
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Piceatannol

Xiamen Eagle Chemical Corporation Contact Supplier

CN
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Trans-Piceatannol

Unit Price: $1.1 /KG EXW

CAS No.: 10083-24-6

Grade: top

Content: 99%

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Jinan topfull chemical co.,ltd Contact Supplier

CN
2 YRS

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Trader Supplier of Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524,Milbemycin oxime,Meloxicam

Piceatannol 98% Purity Stilbene Standard CAS 10083-24-6 Research Grade Reference Standard

Unit Price: $76-80 /G FOB

CAS No.: 10083-24-6

Grade: Analytical Reagent

Content: 98%

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Guide of Piceatannol

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Piceatannol

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