Piceatannol
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Piceatannol
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CAS No:
10083-24-6
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Formula:
C14H12O4
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Chemical Name:
Piceatannol
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Synonyms:
1,2-Benzenediol,4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;3,3′,4,5′-Stilbenetetrol,(E)-;Piceatannol;1,2-Benzenediol,4-[2-(3,5-dihydroxyphenyl)ethenyl]-,(E)-;4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol;Astringenin;trans-3,3′,4,5′-Tetrahydroxystilbene;(E)-Piceatannol;trans-Piceatannol;21100-92-5
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CAS No:
Description
Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppre
Solid
Piceatannol is a stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5. It has a role as a protein kinase inhibitor, a tyrosine kinase inhibitor, an antineoplastic agent, a plant metabolite, a hypoglycemic agent, an apoptosis inducer and a geroprotector. It is a stilbenol, a member of resorcinols, a member of catechols and a polyphenol. It derives from a hydride of a trans-stilbene.|Piceatannol is a polyhydroxylated stilbene extract from the seeds of Euphorbia lagascae, which inhibits protein tyrosine kinase Syk and induces apoptosis. (NCI)
Piceatannol Basic Attributes
244.246
244.24
600-132-4
6KS3LS0D4F
622471|365798
DTXSID6040587
C1195
2907299090
Characteristics
80.9
2.9
Solid
1.5±0.1 g/cm3
215-217 °C
507.3ºC at 760 mmHg
252.2±21.4 °C
1.801
H2O: 0.5 mg/mL
2-8ºC
6.51E-11mmHg at 25°C
Piceatannol Use and Manufacturing
Polyketides [PK] -> Aromatic polyketides [PK13] -> Diphenyl ethers, biphenyls, dibenzyls and stilbenes [PK1309]
Computed Properties
Molecular Weight:244.24
XLogP3:2.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:244.07355886
Monoisotopic Mass:244.07355886
Topological Polar Surface Area:80.9
Heavy Atom Count:18
Complexity:282
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 10083-24-6Grade: Pharmaceutical GradeContent: 99%
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