Disodium 2,2′-dithiobis(ethanesulfonate)
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Disodium 2,2′-dithiobis(ethanesulfonate)
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CAS No:
16208-51-8
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Formula:
C4H10O6S4.2Na
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Chemical Name:
Disodium 2,2′-dithiobis(ethanesulfonate)
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Synonyms:
Ethanesulfonic acid,2,2′-dithiobis-,sodium salt (1:2);Ethanesulfonic acid,2,2′-dithiodi-,disodium salt;Ethanesulfonic acid,2,2′-dithiobis-,disodium salt;2,2′-Dithiodi-1-ethanesulfonic acid disodium salt;Disodium 2,2′-dithiodiethanesulfonate;Dimesna;Disodium 2,2′-dithiobis(ethanesulfonate);Bis(2-sulfoethyl)disulfide disodium salt;BNP 7787;NSC 716976;Tavocept
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CAS No:
Description
White Solid
Dimesna is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.
Disodium 2,2′-dithiobis(ethanesulfonate) Basic Attributes
326.34
325.899902
240-337-2
230R951Y4D
DTXSID6066024
C1365
2930909090
Safety Information
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. (See all compounds classified as Protective Agents.)
2,2'-dithiodiethanesulfonic acid
Disodium 2,2′-dithiobis(ethanesulfonate) Use and Manufacturing
Dimesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.
Ethanesulfonic acid, 2,2'-dithiobis-, sodium salt (1:2): ACTIVE
Computed Properties
Molecular Weight:326.4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:325.89991123
Monoisotopic Mass:325.89991123
Topological Polar Surface Area:182
Heavy Atom Count:16
Complexity:268
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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Disodium 2,2′-dithiobis(ethanesulfonate)
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