Ecadotril
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Ecadotril
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CAS No:
112573-73-6
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Formula:
C21H23NO4S
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Chemical Name:
Ecadotril
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Synonyms:
Glycine,N-[(2S)-2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-,phenylmethyl ester;Glycine,N-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-,phenylmethyl ester,(S)-;Sinorphan;Ecadotril;S 049;BAY-y 7432;BP 1.02
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CAS No:
Characteristics
97.8
3.82490
1.206g/cm3
71 °C
574.5ºC at 760mmHg
301.2ºC
1.578
LD50 i.v. in mice: >100 mg/kg (Duhamel, 1993)
D25 -24.1° (c = 1.3 in methanol)
Drug Information
Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (See all compounds classified as Antidiarrheals.)|Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES). (See all compounds classified as Protease Inhibitors.)
acetorphan
Ecadotril Use and Manufacturing
Sinorphan is an inhibitor of angiotensin-converting enzyme and neutral endopeptidase.
Computed Properties
Molecular Weight:385.5
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:11
Exact Mass:385.13477939
Monoisotopic Mass:385.13477939
Topological Polar Surface Area:97.8
Heavy Atom Count:27
Complexity:485
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes