Elinafide
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Elinafide
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CAS No:
162706-37-8
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Formula:
C31H28N4O4
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Chemical Name:
Elinafide
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Synonyms:
Elinafide;2-[2-[3-[2-(1,3-Dioxobenzo[e]isoindol-2-yl)ethylamino]propylamino]ethyl]benzo[e]isoindole-1,3-dione;N,N'-(Trimethylenebis(iminoethylene))dinaphthalimide;LU 79553;2-[2-[3-[2-(1,3-dioxobenzo[de]isoquinolin-2-yl)ethylamino]propylamino]ethyl]benzo[de]isoquinoline-1,3-dione
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CAS No:
Description
Elinafide is a symmetrical dimeric bis-naphthalimide compound and a topoisomerase II inhibitor with antineoplastic activity. Elinafide contains two neutral chromophores joined by a cationic linker and is capable of bis-intercalation at the TpG and CpA steps of the DNA hexanucleotide. Intercalation inhibits topoisomerase II activity and causing DNA stand breakage, thereby leads to inhibition of DNA, RNA, and protein synthesis.
Characteristics
98.8
3.27010
1.344±0.06 g/cm3(Predicted)
160 °C
750.7±55.0 °C(Predicted)
407.8ºC
1.694
Computed Properties
Molecular Weight:520.6
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:520.21105539
Monoisotopic Mass:520.21105539
Topological Polar Surface Area:98.8
Heavy Atom Count:39
Complexity:821
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes