Efonidipine hydrochloride
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Efonidipine hydrochloride
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CAS No:
111011-53-1
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Formula:
C34H38N3O7P.ClH
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Chemical Name:
Efonidipine hydrochloride
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Synonyms:
3-Pyridinecarboxylic acid,5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[phenyl(phenylmethyl)amino]ethyl ester,hydrochloride (1:1);3-Pyridinecarboxylic acid,5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[phenyl(phenylmethyl)amino]ethyl ester,P-oxide,monohydrochloride;3-Pyridinecarboxylic acid,5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[phenyl(phenylmethyl)amino]ethyl ester,monohydrochloride;1,3,2-Dioxaphosphorinane,3-pyridinecarboxylic acid deriv.;NZ 105;Efonidipine hydrochloride;2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate hydrochloride
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CAS No:
Description
Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).IC50 value: Target: calcium channel blockerin vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(
Characteristics
123
8.95720
169-170ºC
746.9ºC at 760 mmHg
405.5ºC
LD50 in mice (mg/kg): >600 orally (Seto)
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)
5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, P-oxide, hydrochloride
Computed Properties
Molecular Weight:668.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:10
Exact Mass:667.2214153
Monoisotopic Mass:667.2214153
Topological Polar Surface Area:123
Heavy Atom Count:46
Complexity:1170
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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