ENMD 547

N/A

A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.

Molecular Weight:364.32
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:363.15214
Monoisotopic Mass:363.15214
Topological Polar Surface Area:66.6
Heavy Atom Count:21
Complexity:310
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes