ENMD 547
-
ENMD 547
structure -
-
CAS No:
644961-61-5
-
Formula:
C15H30BrN3O2
-
Chemical Name:
ENMD 547
-
Synonyms:
ENMD 547;ENMD-1068 HBr;ENMD-547 (hydrobromide);N1-3-Methylbutyryl-N4-6-aminohexanoyl-piperazine Hydrobromide;CTK8E9595;DTXSID60433259;AKOS015833837;FT-0667861
-
CAS No:
ENMD 547 Use and Manufacturing
A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
Computed Properties
Molecular Weight:364.32
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:363.15214
Monoisotopic Mass:363.15214
Topological Polar Surface Area:66.6
Heavy Atom Count:21
Complexity:310
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
- Hot Searches
- ethanolamine
- 40000/20
- aceclofenac
- cl2o7 compound name
- ebastine
- chlorphenamine