Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
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Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
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CAS No:
867065-53-0
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Formula:
C15H23N3O4S
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Chemical Name:
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
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Synonyms:
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate;tert-butyl 4-(4-(ethoxycarbonyl)thiazol-2-yl)piperazine-1-carboxylate;4-(4-Ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester;ethyl 2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-1,3-thiazole-4-carboxylate
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CAS No:
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Basic Attributes
341.43
341.140930
DTXSID90697463
2934100090
Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate Use and Manufacturing
Tert-butyl piperazine-1-carboxylate (1.8 g, 10 mmol), ethyl 2-bromothiazole-4-carboxylate (2.36 g, 10 mmol) and DIPEA (2.02 g, 20 mmol) were added into 1 , 4-dioxane (15 ml). The mixture was stirred for overnight at 1000 C. When the reaction finished, it was extracted by EA and washed by brine. It was purified by flash column chromatography (PE/EA=5:1-3:1) to afford the yellow solid as product (3.0 g, 88percent).
Computed Properties
Molecular Weight:341.4
XLogP3:2.6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:341.14092740
Monoisotopic Mass:341.14092740
Topological Polar Surface Area:100
Heavy Atom Count:23
Complexity:433
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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