Eplivanserin
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Eplivanserin
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CAS No:
130579-75-8
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Formula:
C19H21FN2O2
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Chemical Name:
Eplivanserin
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Synonyms:
2-Propen-1-one,1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-,O-[2-(dimethylamino)ethyl]oxime,(1Z,2E)-;2-Propen-1-one,1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-,O-[2-(dimethylamino)ethyl]oxime,(Z,E)-;Eplivanserin;SR 46349;148336-83-8
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CAS No:
Description
Eplivanserin is a potent, selective and orally available 5-HT2 receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM.
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)|Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)|Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)
4-((3Z)-3-(2-dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate
Computed Properties
Molecular Weight:328.4
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:328.15870608
Monoisotopic Mass:328.15870608
Topological Polar Surface Area:45.1
Heavy Atom Count:24
Complexity:418
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes