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Mivobulin isethionate

Mivobulin isethionate structure

Mivobulin isethionate 

structure
  • CAS No:

    126268-81-3

  • Formula:

    C17H19N5O2.C2H6O4S

  • Chemical Name:

    Mivobulin isethionate

  • Synonyms:

    canertinib dihydrochloride;CI 980;CI-980;PD 183805;PD-183805;PD183805;Mivobulin isethionate;UNII-8J08028R66;8J08028R66

Description

Mivobulin Isethionate is the isethionate salt of mivobulin, a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis.

Mivobulin isethionate Basic Attributes

451.5

451.15300

8J08028R66

635370

DTXSID50155130

C1357

Characteristics

185

3.34210

483ºC at 760 mmHg

245.9ºC

1.74E-09mmHg at 25°C

Drug Information

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

canertinib dihydrochloride

Mivobulin isethionate Use and Manufacturing

Antineoplastic (microtubule inhibitor).

Computed Properties

Molecular Weight:451.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:451.15255471
Monoisotopic Mass:451.15255471
Topological Polar Surface Area:185
Heavy Atom Count:31
Complexity:595
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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