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Mivobulin

Mivobulin structure

CAS No:
122332-18-7
Formula:
C38H52CaN2O8
Chemical Name:
Mivobulin
Synonyms:
Ethyl N-[(9S)-5-amino-9-methyl-8-phenyl-4,7,10-triazabicyclo[4.4.0] deca-1,3,5,7-tetraen-3-yl]carbamate;Mivobulin [inn];CALCIUM MITIGLINIDE;Mivobulin
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Mivobulin (NSC 613862) is a tubulin inhibitor, binds to tubulin in the region that overlaps the colchicine site, and inhibits tubulin polymerization. Mivobulin (NSC 613862) promotes the formation of abnormal polymers and a GTPase activity in the tubulin dimer. Anti-cancer activity[1].

Mivobulin is a synthetic, colchicine analogue with potential antineoplastic activity. Mivobulin targets and binds to colchicine-binding site on tubulin, thereby inhibiting microtubule polymerization, the assembly of the mitotic spindle and mitosis. This eventually results in cell cycle arrest, apoptosis and a reduction in cellular proliferation.

Mivobulin Basic Attributes

Molecular Weight：

704.91

Exact Mass：

315.18300

UNII：

96U5LG549X

NCI Thesaurus Code：

C87698

Characteristics

PSA：

102

XLogP3：

2.90650

Density：

1.36

Boiling Point：

483ºC at 760mmHg

Flash Point：

245.9ºC

Refractive Index：

1.671

Vapor Pressure：

1.74E-09mmHg at 25°C

Drug Information

MeSH Entry Terms：

ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4-b)pyrazin-7-carbamate

Mivobulin Use and Manufacturing

Antineoplastic (microtubule inhibitor).

Computed Properties

Molecular Weight:325.4
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:325.15387487
Monoisotopic Mass:325.15387487
Topological Polar Surface Area:102
Heavy Atom Count:24
Complexity:478
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Mivobulin

CAS No.: 122332-18-7

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