Ebrotidine
-
Ebrotidine
structure -
-
CAS No:
100981-43-9
-
Formula:
C14H17BrN6O2S3
-
Chemical Name:
Ebrotidine
-
Synonyms:
Benzenesulfonamide,N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-,[N(E)]-;Benzenesulfonamide,N-[[[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-,(E)-;[N(E)]-N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide;Ebrotidine;FI 3542;Ulsanic;Ebrodin
-
CAS No:
Description
Ebrocit was launched in Spain as a gastroprotective agent. It was prepared from 4-bromobenzenesulfonamide in two steps. Ebrocit's activity arises from its ability to antagonize histamine H2-receptors (the first of a new generation) showing 1.5-2.5 times higher affinity than Ranitidine and 2-fold greater affinity than cimetidine which correlates to an antisecretory potency of 1 times and 4-10 times respectively. Cytoand gastroprotection arises from increased gastric mucus producti
Ebrotidine is a sulfonamide.
Characteristics
198
3.37
1.73±0.1 g/cm3(Predicted)
142.5-146 °C
633.0±65.0 °C(Predicted)
360.4±34.3 °C
1.740
6.2E-18mmHg at 25°C
Drug Information
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)
4-bromo-N-(((2-(((-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)benzenesulfonamide
Computed Properties
Molecular Weight:477.4
XLogP3:1.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:475.97585
Monoisotopic Mass:475.97585
Topological Polar Surface Area:198
Heavy Atom Count:26
Complexity:586
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes