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Elsamitrucin

Elsamitrucin structure

CAS No:
97068-30-9
Formula:
C33H35NO13
Chemical Name:
Elsamitrucin
Synonyms:
Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione,10-[[2-O-(2-amino-2,6-dideoxy-3-O-methyl-α-D-galactopyranosyl)-6-deoxy-3-C-methyl-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-;10-[[2-O-(2-Amino-2,6-dideoxy-3-O-methyl-α-D-galactopyranosyl)-6-deoxy-3-C-methyl-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione;Antibiotic BBM 2478A;Elsamicin A;Elsamitrucin;BBM 2478A;Chartreusin analog
Categories:
Biochemical Engineering > Saccharides

Description

The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and human origin. (PMID: 8150873)|Elsamitrucin is an heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. (NCI04)

Elsamitrucin Basic Attributes

Molecular Weight：

653.633

Exact Mass：

653.63

UNII：

ZTV0FOB6NU

NCI Thesaurus Code：

C1080

Characteristics

PSA：

206

XLogP3：

2.42660

Density：

1.57g/cm3

Boiling Point：

913.2ºC at 760mmHg

Flash Point：

506.1ºC

Refractive Index：

1.707

Drug Information

Drug Indication：

Investigated for use/treatment in lymphoma (non-hodgkin's).

MeSH：

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

Biological Half-Life：

36–60 h

Mechanism of Action：

Elsamitrucin induces single strand breaks in DNA and inhibits topoisomerase I and II, enzymes that play an important role in DNA replication.

MeSH Entry Terms：

BBM 2478A

Elsamitrucin Use and Manufacturing

Antineoplastic.

Computed Properties

Molecular Weight:653.6
XLogP3:2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:5
Exact Mass:653.21084017
Monoisotopic Mass:653.21084017
Topological Polar Surface Area:206
Heavy Atom Count:47
Complexity:1210
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Elsamitrucin

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
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Elsamitrucin

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