Ethyl-pyrazin-2-yl-aMine

A novel process for the reaction of a secondary amine by reaction of 2-aminopyrazine with triethylamine, comprising the steps of:Under nitrogen protection, Under nitrogen protection, 2-aminopyrazine (95 mg, 1 mmol) was added to a 50 mL Schlenk tube, Triethylamine (304 mg, 3 mmol), [(Bt) 2 * Ir * P (nBu) 3] OTf (9.6 mg, 0.01 mmol, 1.0 molpercent), Add 2.0mL xylene;The reaction solution was reacted at 155 ° C for 10 h, The resulting solution was separated on a silica gel column from 200 to 300 mesh (eluent 1:10 ethyl acetate / petroleum ether)After removal of the solvent, To get the product.Yield: 78percent.

Molecular Weight:123.16
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:123.079647300
Monoisotopic Mass:123.079647300
Topological Polar Surface Area:37.8
Heavy Atom Count:9
Complexity:74.7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes