1,1,2,3,3,3-Hexachloro-1-propene

248.7

247.810166

217-560-9

740VOV69VZ

7297

3382|3082

DTXSID7062039

WATER-WHITE LIQUID

2903299090

1.7632 at 20 °C/4 °C

-72.9 °C

209.5 °C

Index of Refraction= 1.5091 at 20 °C

6.84e-05 M|MIscible with alcohol, ether, chlorinated solvents|In water= 17 mg/l at 25 °C

0.24 mmHg|0.244 mm Hg at 25 °C /from experimentally-derived coefficients/

Insoluble in water.

Halogenated Organic Compounds

HEXACHLOROPROPENE is substantially less reactive than less heavily chlorinated propenes. Nonflammable and not polymerizable. May be incompatible with strong oxidizing agents, strong reducing agents, many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U243, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P260, P261, P264, P271, P280, P284, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P320, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3382 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Chloropropanes and chloropropenes cause ... tearing & irritation of mucous membranes. /Chloropropanes and chloroproenes/

U243; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

U243; As stipulated in 40 CFR 261.33, when hexachloropropene, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Hexachloropropene's production and use as a chemical intermediate in the production of uranium tetrachloride(1), as a solvent, plasticizer, and its use in hydraulic fluid(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexachloropropene will have moderate mobility in soil(SRC). Volatilization of hexachloropropene may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 1.6X10-3 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Volatilization from dry soil surfaces(SRC) is expected based on a extrapolated vapor pressure of 0.244 mm Hg(4,SRC).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexachloropropene may adsorb to suspended solids and sediment in water(SRC). Hexachloropropene may volatilize from water surfaces(1,SRC) based on an estimated Henry's Law constant of 1.6X10-3 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Estimated volatilization half-lives for a model river and model lake are 5 hours and 7 days, respectively(1,SRC). According to a classification scheme(5), an estimated BCF value of 130(1,SRC), from a measured water solubility(4), suggests that bioconcentration in aquatic organisms is high(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexachloropropene, which has an extrapolated vapor pressure of 0.244 mm Hg at 25 °C(2,SRC), will exist solely as a vapor in the ambient atmosphere. Vapor-phase hexachloropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 21 days(3,SRC).

The rate constant for the vapor-phase reaction of hexachloropropene with photochemically-produced hydroxyl radicals has been estimated as 7.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 21 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

An estimated BCF value of 130 was calculated for hexachloropropene(SRC), using a measured water solubility of 17 mg/l(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for hexachloropropene can be estimated to be about 470(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that hexachloropropene has moderate mobility in soil(SRC).

The Henry's Law constant for hexachloropropene is estimated as 1.6X10- 3 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that hexachloropropene will volatilize from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 5 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 7 days(2,SRC). Hexachloropropene's values for vapor pressure, 0.244 mm Hg(3,SRC) and Henry's Law constant(1,SRC) indicate that volatilization from dry and moist soil surfaces may occur(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1821 workers (273 of these are female) are potentially exposed to hexachloropropene in the USA(1). Occupational exposure may be through inhalation and dermal contact with this compound at workplaces where hexachloropropene is produced or used(SRC).

An investigation was conducted to validate the hypothesis that the nephrotoxicity of halogenated alkenes may be attributable to hepatic glutathione (GSH) S-conjugate formation and ultimately, to bioactivation by renal cysteine conjugate beta-lyase. The bioactivating mechanism accounting for the organ selective tumor induction called for the conjugation of the parent cmpd with GSH and catalysis by hepatic GSH S-transferases, which resulted in formation of haloakyl and halovinyl glutathione S-conjugates. Trichloroethene, tetrachloroethene, hexachlorobutadiene, perfluoropropene, trichlorotrifluoropropene and dichloroacetylene incubations with rat liver microsomes and in the isolated rat liver with the bile and were translocated to the kidney either intact or following metabolism. The resulting cysteine S-conjugates were then metabolized to thioacylchlorides and thioketenes. DNA interacted with these potent electrophiles causing mutagenicity in bacteria, genotoxicity in cultured renal cells, and cytotoxicity in kidney cells. The cysteine S-conjugates were possibly acetylated to the corresponding mercapturic acids, as an alternative to beta-lyase catalyzed cleavage. These mercapturic acids have been identified in urine. /Results indicate/ that the organotropic carcinogenicity is apparently due to the ability of the kidney to concentrate GSH and cysteine S-conjugates and intensive metabolism of GSH S-conjugates to cysteine S-conjugates in this organ.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)

Chloropropanes and chloropropenes cause contact dermatitis, headaches vertigo, tearing, irritation of mucous membranes, and when ingested, liver damage in humans. /Chloropropanes and chloroproenes/

hexachloropropene

1-Propene, 1,1,2,3,3,3-hexachloro-: ACTIVE|S - indicates a substance that is identified in a final Significant New Use Rule.

EAD Method 1625. Semivolatile Organic Compounds by Isotope Dilution GC/MS. Capillary GC/MS analysis for water and sludge samples. ML= 10 ug/l.|OSW Method 8270B. Determination of Semivolatile Organic Compounds by Gas Chromatography/Mass Spectrometry (GC/MS): Capillary Column Technique. EQL=10 ug/l.|OSW Method 8270C. Semivolatile Organic Compounds by Gas Chromatography/Mass Spectrometry (GC/MS): Capillary Column Technique.|SFSAS Method SFSAS_29. Extraction and Analysis of Organics in Biological Tissue. Capillary GC/MS analysis. LOQ= 2.0 mg/kg.